神经妥乐平药理作用及临床应用现状  

Pharmacological action and clinical application progress of neurotropin

作　　者：李波[1] 郭星 孙超[1] 段会全[1] 张焱 赵晨曦 闫佳银 姚雪[1] 冯世庆[1] LI Bo;GUO Xing;SUN Chao;DUAN Hui-quan;ZHANG Yan;ZHAO Chen-xi;YAN Jia-yin;YAO Xue;FENG Shi-qing(Department of Orthopedic, Tianjin Medical University General Hospital, Tianjin 300052, China;College of Stomatology, Tianjin Medical University, Tianjin 300070, China)

机构地区：[1]天津医科大学总医院骨科,天津300052 [2]天津医科大学口腔医学院,天津300070

出　　处：《中国临床药理学杂志》2018年第8期1005-1008,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81672171;81330042;81620108018);国家科技部中俄合作专项基金资助项目(2014DFR31210);天津市科委重点基金资助项目(14ZCZDSY00044;13RCGFSY19000);天津医科大学总医院青年孵育基金资助项目(ZYYFY2015008)

摘　　要：神经妥乐平是将牛痘疫苗接种于家兔皮肤,从其免疫炎症组织中提取的去除蛋白的小分子生物活性混合物,临床上广泛应用于疼痛治疗及抗过敏治疗等方面,特别是对神经病理性疼痛具有独特的疗效。神经妥乐平的药理作用集中在调节免疫系统功能、调节疼痛信号传导、保护细胞及神经修复、抑制炎症反应等方面。其在临床上广泛用于骨科各种急慢性疼痛疾病、神经内科中脑缺血、神经痛及神经炎症疾病、皮肤科瘙痒症、过敏性疾病等。本文综述了神经妥乐平的相关研究,阐明其药理作用及目前的临床应用。Neurotropin is an extract micromolecule mixture containing many conjugated polysaccarides isolated from the skin or tissues of rabbits which have been inoculated with the living cowpox virus. Neurotropin is widely used in pain treatment and anti-allergy treatment,especially for neuropathic pain,it has a unique effect. Pharmacological effects of neurotropin focused on regulating immune system function,regulating pain signaling,protecting cells and nerves,and suppressing inflammatory reactions. It is widely used in clinical various acute and chronic orthopedic pain diseases,neurological cerebral ischemia,neuralgia and neuroinflammation diseases, dermatological pruritus, allergic diseases. This review focuses on the pharmacological action and clinical application progress of neurotropin.

关 键 词：神经妥乐平 神经保护 药理作用 临床应用 疼痛 

分 类 号：R977.6[医药卫生—药品]