海南省汉族人群HLA-B~*5801基因多态性与别嘌醇所致不良反应的相关性研究  

Relationship between HLA-B~*5801 Gene Polymorphism and Allopurinol-induced ADR in Han Population of Hainan Province

作　　者：云雄 吴丹娜[1,2] 韩方璇[2] 黄春新[2] 彭文兴[1] YUN Xiong;WU Danna;HAN Fangxuan;HUANG Chunxin;PENG Wenxing(Dept. of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410008, China;Dept. of Pharmacy, Hainan Provincial People＇s Hospital, Haikou 570311, China)

机构地区：[1]中南大学湘雅二医院药学部,长沙410008 [2]海南省人民医院药学部,海口570311

出　　处：《中国药房》2018年第9期1256-1259,共4页China Pharmacy

基　　金：海南省卫生和计划生育委员会行业科研项目(No.15A200087;16A200033)

摘　　要：目的:探讨海南省汉族人群HLA-B~*5801基因多态性与别嘌醇所致不良反应的相关性。方法:对海南省人民医院2015年9月-2017年9月住院的149例使用别嘌醇的患者采用原位杂交荧光染色分析技术检测其HLA-B~*5801等位基因,根据其不良反应情况分为耐受组和不良反应组,应用Woolf’s公式计算比值比(OR),分析HLA-B~*5801等位基因与别嘌醇不良反应发生的相关性。结果:149例患者中耐受组133例,其中17.29%(23/133)携带HLA-B~*5801等位基因;不良反应组16例,其中93.75%(15/16)携带HLA-B~*5801等位基因。发生不良反应的16例患者中,13例为皮肤及其附件损伤、1例为全身性损害,1例为胃肠系统损害,1例为中枢及外周神经系统损害。携带HLA-B~*5801等位基因患者发生不良反应的风险显著高于不携带HLA-B~*5801等位基因患者(OR:71.74,95%CI:9.02~570.55,P<0.000),其中发生皮肤及其附件损伤与HLA-B~*5801等位基因也呈强相关性(OR:57.39,95%CI:7.11~463.50,P<0.000)。结论:海南省汉族人群HLA-B~*5801等位基因与别嘌醇所致不良反应具有强相关性,建议本地区汉族患者开始服用别嘌醇前先检测HLA-B~*5801等位基因,有助于减少别嘌醇所致不良反应的发生。OBJECTIVE：To investigate the relationship between HLA-B~＊5801 gene polymorphism and allopurinol-induced ADR in the Han population of Hainan Province. METHODS：The in-situ hybridization fluorescence staining analysis technique was used to detect HLA-B~＊5801 allele of 149 inpatients receiving allopurinol in Hainan Provincial People＇s Hospital during Sept.2015-Sept. 2017. They were divided into tolerance group and ADR group according to ADR. Woolf＇s formula was used to calculate OR. The correlation of HLA-B~＊5801 allele with the occurrence of allopurinol-induced ADR was analyzed. RESULTS：Of 149 patients,there were 133 cases in tolerance group,among which 17.29%（23/133）carried HLA-B~＊5801 allele. There were 16 cases in ADR group,among which 93.75%（15/16） carried HLA-B~＊5801 allele. Among 16 ADR patients,13 patients suffered from lesion of skin and its appendents;1 patient suffered from systemic damage;1 patient suffered from gastrointestinal systemic damage;1 patient suffered from central and peripheral nervous system damage. The risk of ADR in patients with HLA-B~＊5801 allele was significantly higher than patients without HLA-B~＊5801 allele（OR：71.74,95% CI：9.02-570.55,P〈0.000）. The lesion of skin and its appendents was strongly associated with HLA-B~＊5801 allele（OR：57.39,95% CI：7.11-463.50,P〈0.000）.CONCLUSIONS：HLA-B~＊5801 allele is strongly associated with allopurinol-induced ADR. It is suggested that HLA-B~＊5801 allele of Han patients should be detected before taking allopurinol,which helps to reduce the incidence of allopurinol-induced ADR.

关 键 词：HLA-B＊5801 别嘌醇 基因多态性 不良反应 海南省 汉族 

分 类 号：Q343.15[生物学—遗传学]