大鼠血压和脉搏的无创测试及其参考值的制订  

Noninvasive test and reference formulation of blood pressure and pulse in normal rats

作　　者：刘俊丹 李紫元 邱文才 梁伟燊 唐陆平 何永明[1] LIU Jundan;LI Ziyuan;QIU Wencai;LIANG Weishen;TANG Luping;HE Yongming(Department of Veterinary Medicine, Foshan University, Foshan 528000, Chin)

机构地区：[1]佛山科学技术学院兽医系

出　　处：《黑龙江畜牧兽医》2018年第7期102-104,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：“十二五”农村领域国家科技计划项目(2011BAD34B00);农业部行业科技专项(201003060-09);广东省省级科技计划项目(2015A040404048);佛山市科技计划项目(佛财工[2015]143)

摘　　要：为了获取正常大鼠无创血压和脉搏的基础数据,对心血管系统疾病药（毒）理学研究提供参考,试验以SD大鼠为研究对象,采用尾套法和MC4000血压分析系统连续监测血压变化,包括收缩压（systolic blood pressure,SBP）、舒张压（diastolic blood pressure,DBP）、平均动脉压（mean arterial pressure,MAP）和脉搏（pulse,P）变化。结果表明：不同时间段（6：00,12：00,18：00,24：00）大鼠的收缩压、舒张压、平均动脉压和脉搏均差异不显著（P〉0.05）;雌雄大鼠之间的收缩压、舒张压、平均动脉压和脉搏均差异不显著（P〉0.05）;大鼠收缩压参考范围为130-176 mmHg,舒张压参考范围为102-144mmHg,平均动脉压参考范围为111-151 mmHg,脉搏参考范围为276-412次/min。说明1 d中不同时间段大鼠的血压和脉搏无显著变化,且不同性别对大鼠的血压和脉搏无影响。The aim of the present study was to obtain basic data of noninvasive blood pressure and pulse in normal rats,it was considered as reference for studies of cardiovascular pharmacology and toxicology. The changes of blood pressure（Systolic blood pressure,SBP; diastolic blood pressure,DBP; mean arterial pressure,MAP and pulse,P） of SD（Sprague dawley） rats were continuously monitored by tail-cuff method and MC 4000 blood pressure analysis system. The results showed that the SBP,DBP,MAP and P were not significantly different in rats at different time points（6： 00,12： 00,18： 00,24： 00）（P0. 05）. And there was no significant difference in SBP,DBP,MAP and P between female and male rats（P0. 05）. The SBP of the rats was in the range of 130-176 mm Hg,DBP was 102-144 mmHg,MAP was 111-151 mm Hg,and P was 276-412 beats/min. The results indicated that there were no significant changes in blood pressure and pulse in different periods of one day,and gender also had no effect on blood pressure and pulse.

关 键 词：无创测试 血压 脉搏 参考值 大鼠 

分 类 号：S865.12[农业科学—野生动物驯养] R54[农业科学—畜牧兽医]