隐匿性乙肝病毒感染发生机制和临床意义研究进展  

A review on mechanism and clinical implication of occult hepatitis B virus infection

作　　者：李伟[1] 武文[2] 黄象艳[2] Li Wei;Wu Wen;Huang Xiangyan(The Second Clinic , Department of Blood Transfusion , General Hospital of Jinan Military Command, Jinan 250002, Chin)

机构地区：[1]济南军区总医院第二门诊部,250002 [2]济南军区总医院输血科,250002

出　　处：《中华实验和临床病毒学杂志》2018年第2期220-224,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家自然科学基金青年基金资助项目（81101321）

摘　　要：隐匿性乙肝病毒感染（Occult hepatitis B infection，OBI）患者中病毒DNA水平极低，血清中难以检测到常规衄清学标志物，即乙肝表面抗原（HBsAg），对临床诊治和输血安全带来了挑战。其相关机制和临床意义越来越受到关注。0BI发生机制复杂，可能涉及宿主因素、病毒本身的因素以及其他病毒或非病毒因素。OBI存在传播HBV的风险，可被重新激活并会导致肝脏疾病加重。The level of viral DNA in patients with occult hepatitis B virus infection （OBI） is very low, and it is difficult to detect the conventional serum marker-HBsAg. OBI brought challenges to the clinical diagnosis and treatment and blood transfusion safety. The mechanism involved in OBI and the clinical implication are getting more and more attention. OBI has a complex mechanism that may involve host factors, the virus itself, and other viral or nonviral factors. OBI has the risk of HBV transmission. HBV can be reactivated and the liver disease can be aggravated in patients with OBI.

关 键 词：隐匿性乙肝病毒感染 发生机制 临床意义 

分 类 号：R512.62[医药卫生—内科学]