电感耦合等离子体发射光谱法测定原料药(异丙托溴铵)中的硼杂质含量  

Determination of boron impurity in raw material(ipratropium bromide) by inductively coupled plasma emission spectrometry

作　　者：池海涛[1] 徐聪[1] 乐胜锋[1] 王尉[1] 赵婷[1] 赵毅[1] 贺俊智 Chi Haitao;Xu Cong;Le Shengfeng;Wang Wei;Zhao Ting;Zhao Yi;He Junzhi(Beijing Center for Physical and Chemical Analysis ~ Beijing Key Laboratory of Organic Material Detection Technology and Quality Evaluation ＆ Beijing Academy of Science and Technology, Key Laboratory of Analysis and Testing Technology, Beijing 100094, China)

机构地区：[1]北京市理化分析测试中心有机材料检测技术与质量评价北京市重点实验室北京市科学技术研究院分析测试技术重点实验室,北京100094

出　　处：《分析仪器》2018年第2期43-45,共3页Analytical Instrumentation

基　　金：北京市财政资金改革与发展课题(2018ZL0101)

摘　　要：采用电感耦合等离子体发射光谱(ICP-AES)法检测异丙托溴铵中硼的含量,进行了原料药(异丙托溴铵)中硼杂质残留检验方法开发的研究。通过配制系列标准溶液,验证标准曲线方程和相关系数,确定该方法的相关系数r均为0.9999。利用该检测方法测硼回收率在97%~99%之间。方法检出限可达到45.05μg/kg,方法定量限为136.5μg/kg。精密度实验RSD均在2%以内。可以用于原料药(异丙托溴铵)中催化剂的测定。The content of boron in ipratropium bromide was determined by inductively coupled plasma atomic emission spectrometry（ICP-AES）,and a method for the determination of boron impurity residues in raw material drug（ipratropium bromide）was developed.A series of standard solutions were prepared by which the standard curve equation and the correlation coefficient were verified.The results showed the correlation coefficient of the method was 0.9999.The boron recoveries were favorable by using this method.The detection limit of the method was 45.05μg/kg.The quantitative limit was 136.5μg/kg.The precision based on RSD tests were below 2%.The method can be used for the determination of catalyst in raw material drug（ipratropium bromide）.

关 键 词：电感耦合等离子体发射光谱法 异丙托溴铵 含量测定 硼 

分 类 号：O657.31[理学—分析化学] TQ460.72[理学—化学]