丙型肝炎病毒感染人群的戊型肝炎流行特征分析  

Epidemiological characteristics of hepatitis E in patients with hepatitis C virus infection

作　　者：肖红霞 张守德 周昇 宁玉[3] 万琴 张雪峰 辛玉璇 XIAO Hongxia;ZHANG Shoude;ZHOU Sheng;NING Yu;WAN Qin;ZHANG Xuefeng;XIN Yuxuan(Center for Disease Control and Prevention of Hannan District in Wuhan, Hubei 430090, Chin)

机构地区：[1]武汉市汉南区疾病预防控制中心,湖北430090 [2]安陆市疾病预防控制中心 [3]孝感市疾病预防控制中心

出　　处：《医学动物防制》2018年第5期417-419,422,共4页Journal of Medical Pest Control

基　　金：湖北省卫生和计划生育委员会面上项目(WJ2017M174;WJ2017M240)

摘　　要：目的了解丙型肝炎病毒(HCV)感染人群中的戊型肝炎病毒(HEV)重叠感染流行情况,为更有效地开展丙型肝炎和戊型肝炎防治工作提供科学依据。方法采集2015年10月~2016年12月孝感地区HCV感染者的血清进行抗-HEV Ig G、抗-HEV IgM筛查。对调查发现的抗-HEV IgM阳性样本进行核酸检测和基因分型。对HCV感染者进行肝功能筛查以及收集其人口学资料进行分析。结果 164例HCV感染者中抗-HEV Ig G阳性率为34.15%,抗-HEV IgM阳性率为2.44%%(4/164)。抗-HEV Ig G阳性率在性别和年龄上差异均无统计学意义(P<0.05),4个抗-HEV IgM阳性个体中异常指标2个,异常个体值分别为ALT 328.05 U/L、AST 259.80 U/L、总胆红素(TBIL)107.65μmol/L、直接胆红素(DBIL)5.32μmol/L和ALT 32.01 U/L、AST 40.20 U/L、总胆红素(TBIL)10.65μmol/L、直接胆红素(DBIL)9.32μmol/L,其中1个HEV RNA为阳性,基因型为Ⅳd亚型。结论 HCV感染者HEV既往感染和急性感染较高。对有HCV感染史的人群进行HEV筛查很有必要,同时要采用综合治疗。Objective To understand the overlapping infection prevalence of hepatitis E virus（ HEV） in the crowd infected hepatitis C virus,and provide the scientific basis for prevention and control hepatitis C and hepatitis E. Methods Serum samples of164 people infected HCV were collected in October 2015 to December 2016 in Xiaogan and screened anti-HEV IgG and anti-HEV IgM. Nucleic acid detection and genotyping were taken by the anti-HEV IgM positive samples. 164 HCV patients were screened liver function and their demographic data were gathered. Results The anti-HEV IgG positive rate was 34. 15% and anti-HEV IgM positive rate was 2. 44%（ 4/164） among 164 HCV patients. Anti-HEV IgG positive rate had no statistical significance in gender and age（ P〈0. 05）. Two normal liver function index,and two liver function abnormalities among 4 anti-HEV IgM individuals. One abnormal individual indexes of ALT, AST, TBIL, and DBIL were 328. 05 U/L,259. 80 U/L,107. 65 μmol/L and 5. 32 μmol/L,respectively. The other indexes of ALT,AST,TBIL,and DBIL were 32. 01 U/L,40. 20 U/L,10. 65 μmol/L,and 9. 32 μmol/L,respectively. One HEV RNA was positive with Ⅳ d sub-genotype. Conclusion Previons infection and acute infection of HCV populations were higher. HEV screening was necessary for people with a history of HCV infection,and comprehensive treatment were adopted.

关 键 词：戊型肝炎病毒 丙型肝炎病毒 血清流行病学 基因型 混合感染 

分 类 号：R512.6[医药卫生—内科学]