右美托咪定在ERCP直视手术麻醉中对患者BIS影响的临床研究  

Clinical Study on Dexmedetomidine's Effect on BIS of Patients with ERCP Open Surgery Anesthesia

作　　者：张惠珍[1] 于振峰[1] ZHANG Hui-zhen;YU Zhen-feng(Department of Anesthesiology, Baotou City Mongolian and Traditional Chinese Medicine Hospital, Baotou, Inner Mongolia, 014040)

机构地区：[1]包头市蒙医中医医院麻醉科,内蒙古包头014040

出　　处：《智慧健康》2018年第5期106-107,共2页Smart Healthcare

摘　　要：目的探讨分析右美托咪定(恒瑞-艾贝宁)在内镜下逆行胰胆管造影术(ERCP)直视手术麻醉中对患者脑电双频指数(BIS)值的影响。方法采用随机分组的方式将2016年1月至2017年2月间收治的96例内镜下逆行胰胆管造影术(ERCP)手术患者分为两组,对照组麻醉用药为丙泊酚,实验组麻醉用药为右美托咪定,评估两组不同时点的脑电双频指数(BIS)值变化,统计舒芬太尼用量、苏醒时间和清醒时间并观察用药不良反应情况。结果与对照组相比,实验组T2、T4、T5时点的BIS值明显更低,独立样本t检验提示两组数据差异具有统计显著性(P<0.05);实验组T1-T5间的脑电双频指数(BIS)值明显低于T0时点(P<0.05)。实验组舒芬太尼用量更少,苏醒时间以及清醒时间更短,与对照组相比差异具有统计学意义(P<0.05);两组呼吸抑制、心动过缓、低血压及躁动等不良反应发生率相近,卡方检验提示两组数据差异无统计显著性(P>0.05)。结论内镜下逆行胰胆管造影术(ERCP)手术中应用右美托咪定既可满足临床麻醉需要,患者脑电双频指数显著降低,镇静效果显著,手术过程平稳且安全可靠,值得临床应用。Objective To investigate effect of dexmedetomidine（Hengrui-Abotning） on bispectral index value（BIS） of patients with endoscopic retrograde cholangiopancreatography（ERCP） open surgery anaesthesia. Methods Divide 96 cases ERCP open surgery from January 2016 to February 2017 into two groups by random grouping method. Control group was treated with propofol anesthesia, and experimental group with dexmedetomidine anesthesia. Evaluate changes of BIS value at different time points of two groups, and carry on statistics of fentanyl dosage, wake-up time and awake time, observe adverse reactions of medicine. Results Compared with control group, BIS value at time point of T2, T4 and T5 of experimental group was significantly lower. Independent sample t test suggested data differences showed statistical significance between two groups,（P〈0.05）, and BIS value between T1-T5 of experimental group was significantly lower than T0 time point,（P〈0.05）. Sufentanil dosage of experimental group was less than control group, wake-up time and awake time was less than control group, differences showed statistical significance between two groups,（P〈0.05）. Adverse reactions incidence of respiratory depression, bradycardia, hypotension and restlessness was similar between two groups, Chi square test suggested data difference showed no statistical significance between two groups,（P〉0.05）. Conclusion Dexmedetomidin can not only meet needs of clinical anesthesia, but significantly reduce BIS of patients with ERCP surgery, it has remarkable sedation effect, stable and safe operation process, which is worthy of clinical application.

关 键 词：内镜下胰胆管造影术 右美托咪定 脑电双频指数 临床 

分 类 号：R614[医药卫生—麻醉学]