宣痹汤治疗腰椎间盘突出症的疗效及对血清TNF-a和IL-1的影响  

Therapeutic study of Xuanbitang in treatment of lumbar disc herniation and its effect on serum TNF-a and IL-1

作　　者：茹国华 RU Guo-hua.(Department of Orthopaedics, Traditional Chinese Medicine Hospital of Sanmenxia City, Henan 450000, China)

机构地区：[1]河南省三门峡市中医院骨科,450000

出　　处：《淮海医药》2018年第3期256-258,共3页Journal of Huaihai Medicine

基　　金：河南省教育厅科学技术研究重点项目指导计划项目(14B360018)

摘　　要：目的:探讨宣痹汤治疗腰椎间盘突出症湿热痹阻证的疗效及对血清TNF-a和IL-1的影响。方法:选择90例符合条件的患者随机分为治疗组和对照组,各45例。治疗组口服双氯芬酸钠联合宣痹汤,对照组口服双氯芬酸钠,疗程均为2个月。观察治疗前后改良日本骨科学会腰痛评分量表(JOA)和Oswestry功能障碍指数问卷(ODI);检测肿瘤坏死因子-a(TNF-a)及白细胞介素-1(1L-1)的水平。比较2组临床疗效和不良反应发生率。结果:治疗组总有效率97.56%,明显高于对照组的82.05%(P<0.05)。治疗组JOA,ODI评分,血清TNF-a,IL-1水平改善优于对照组,2组比较差异有统计学意义(P<0.05)。结论:宣痹汤治疗腰椎间盘突出症湿热痹阻证疗效明显,不良反应发生率低,其作用机制可能与改善血清TNF-a,IL-1水平有关。Objective：To observe the effect of Xuanbitang on the treatment of lumbar disc herniation syndrome and its effect on serum TNF-α and IL-1. Methods ：90 cases of lumbar disc herniation syndrome were randomly divided into a treatment group and a control group, 43 cases in each group. The control group was treated with diclotenac sodium while the treatment group with diclotenac sodium combined with Xuanbitang, both tor 2 months. The improvements of the Japanese orthopedics score （ JOA ） and Oswestry tunctional disorder index （ODI） scores before and after the treatment were observed. The level of tumor necrosis factor-α （TNF-α） and interleukin- 1 （ IL-1 ） was detected. The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results ：The to- tal effective rate of the treatment group was 97.56% , higher than 82.05% in the control group （ P 〈 0.05 ）. The treatment groupg JOA, ODI scores, serum TNF-α and IL-1 improved better than the control group. Conclusion：The effect of Xuanbitang on lumbar disc herniation is obvious and the incidence of adverse reactions is low. The mechanism of action may be related to the improvement of serum TNF-α, IL-1 level.

关 键 词：腰椎 椎间盘移位 宣痹汤 双氯芬酸钠 湿热痹阻证 

分 类 号：R681.53[医药卫生—骨科学]