临床药师基于基因多态性和药物相互作用参与华法林个体化抗凝的临床实践  

Clinical Practice of Individualized Anticoagulation of Warfarin by Clinical Pharmacists Based on Gene Polymorphism and Drug Interaction

作　　者：惠红岩[1] 周祥[1] 王学惠[1] 邓智建[1] Hui Hongyan;Zhou Xiang;Wang Xuehui;Deng Zhijian(The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China)

机构地区：[1]新乡医学院第一附属医院,卫辉453100

出　　处：《中国药事》2018年第4期546-549,共4页Chinese Pharmaceutical Affairs

基　　金：河南省教育厅科学技术发展计划项目(编号142300410191)

摘　　要：目的:探讨临床药师参与华法林个体化抗凝的临床实践。方法:参与1例INR频繁波动的华法林个体化给药的过程。结果:临床药师结合基因检测结果与药物相互作用原理,给出合并用药方案调整的建议,并对患者进行华法林用药教育。结果:基因多态性只是华法林个体化治疗过程中的部分影响因素,将其与环境因素有机结合起来,才能真正做到华法林的个体化抗凝治疗,提高抗凝治疗的成功率。Objective： To explore the clinical practice of individualized anticoagulation of Warfarin by clinical pharmacists. Methods： Clinical pharmacists participated in the process of individualized administration of Warfarin in 1 case with frequent fluctuation of 1NR. Results： The combined medication regimen was suggested and the patient was educated about the medication of Warfarin by clinical pharmacists based on gene testing results and principle of drug interaction. Conclusion： Gene polymorphism was only part of the influencing factors in the process of individualized medication of Warfarin. The combination of environmental factors with gene polymorphisms could truly achieve the individualized anticoagulation therapy and improve the success rate of anticoagulation therapy.

关 键 词：基因多态性 药物相互作用 华法林 个体化给药 

分 类 号：R969.3[医药卫生—药理学]