利福喷丁联合胰岛素强化降糖对糖尿病合并肺结核的疗效  

Observation of Curative Effect of Rifapentine Combined with Insulin Intensive Hypoglycemic Therapy in the Treatment of Diabetes Complicated with Pulmonary Tuberculosis

作　　者：宋丽 岳峰[1] SONG Li;YUE Feng(Department of Infection of The First Affiliated Hospital of Henan Science and Technology University, Luoyang, Henan475001)

机构地区：[1]河南科技大学第一附属医院感染科,洛阳475001

出　　处：《实用中西医结合临床》2018年第2期1-2,5,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨利福喷丁联合胰岛素强化降糖治疗对糖尿病合并肺结核的疗效。方法:选取2016年1月~2017年1月我院感染科收治的96例糖尿病合并肺结核患者作为研究对象,随机分为对照组和观察组,每组48例。对照组给予3HRZE/6HRE抗结核和口服降糖药控制血糖治疗,观察组给予3HL2ZE/6HL2E抗结核和胰岛素强化降糖治疗。比较两组患者治疗期间的血糖指标和不良反应发生率,在治疗3个月末,比较两组患者抗结核治疗的有效率。结果:治疗后,观察组患者的血糖指标明显低于对照组,差异有统计学意义,P<0.05;治疗3个月末,观察组患者的抗结核治疗有效率明显高于对照组,差异有统计学意义,P<0.05;观察组的不良反应发生率小于对照组,差异有统计学意义,P<0.05。结论:采用利福喷丁联合胰岛素强化治疗糖尿病合并肺结核,可以使患者血糖控制效果更为理想,且有助于提高抗结核治疗有效率,临床疗效可靠。Objective： To observe the curative effect o f Rifapentine combined with insulin intensive hypoglycemic therapy in the treatment of diabetes complicated with pulmonary tuberculosis. Methods： From January 2016 to January 2017, selected 96 patients with diabetes complicated with pulmonary tuberculosis as the research objects, they were randomly divided into the control group and the observation group, with 48 cases in each group. The control group was given 3 HRZE/6 HRE anti-tuberculosis and oral hypoglycemic drugs treatment, and the observation group was given 3 HL2 ZE/6 HL2 E anti-tuberculosis and insulin intensive treatment. During the treatment,observed the effect of blood glucose control and the adverse reaction rates of the two groups. 3 months after the treatment, compared the tuberculosis absorption situation and clinical effect of the two groups. Results： After the treatment, the blood glucose index of the observation group was significantly lower than that of the control group, the difference was statistically significant, P0.05; at the end of3 months in the treatment, the effective rate of anti tuberculosis treatment in the observation group was significantly higher than that in the control group, the difference was statistically significant, P 0.05; the incidence of adverse reactions in the observation group was less than that in the control group, the difference was also statistically significant, P0.05. Conclusion： Use Rifapentine combined with insulin intensive hypoglycemic therapy in the treatment of diabetes complicated with pulmonary tuberculosis, can make blood glucose control effect more ideal, and is helpful to improve the efficiency of anti tuberculosis treatment, clinical curative effect is reliable.

关 键 词：糖尿病 肺结核 利福喷丁 胰岛素强化 

分 类 号：R587.2[医药卫生—内分泌]