允许性高碳酸血症的生理影响及在麻醉中的应用  

Effects and applications of permissive hypercapnia during general anesthesia

作　　者：程若竹 陈宏志[1] Cheng Ruozhu;Chen Hongzhi.(Department of Anesthesiology, Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China)

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳110004

出　　处：《中国医师进修杂志》2018年第2期178-182,共5页Chinese Journal of Postgraduates of Medicine

基　　金：辽宁省自然科学基金（2014021087）

摘　　要：全身麻醉手术后肺部并发症不仅延长住院时间，增加住院费用，严重影响患者术后康复，同时还是患者围手术期死亡的重要原因，因而备受麻醉医生重视。近年来，肺保护通气策略在术中的应用逐步开始得到重视，这些措施常伴随一定程度的高碳酸血症。各项研究显示机体对高碳酸血症有一定的耐受性并且允许性高碳酸血症可以减少机体肺损伤时的炎性反应，也是肺保护通气重要组成部分。本文旨在综述允许性高碳酸血症对机体的影响以及在全身麻醉中的应用进展。Postoperative pulmonary complications draws anesthetists′ attention as it can be associated with prolonged postoperative hospital stays, increased hospitalization expense, retardeding postoperative recovery and increased hospital mortality. In recent years, lung protective ventilation strategy has been applied during operation under general anesthesia, and current protective lung ventilation strategies generally involve some degree of hypercapnia. Increasing evidences support that hypercapnia is well tolerated and hypercapnia can attenuate the inflammatory response during lung injury, which would assign it a specific role within lung protection strategies during mechanical ventilation. In this paper, we summarize the influence of permissive hypercapnia on the body and the research development in the application of permissive hypercapnia in general anesthesia.

关 键 词：肺通气 麻醉 全身 允许性高碳酸血症 综述 

分 类 号：R614[医药卫生—麻醉学]