应用遗传修饰蚊虫控制蚊媒传染病的研究进展  

RESEARCH PROGRESS OF GENETIC MODIFIED MOSQUITOES FOR THE CONTROL OF MOSQUITO-BORNE INFECTIOUS DISEASES

作　　者：郑学礼 ZHENG Xue-Li(Department of pathogenic Biology, College of Public Health, Southern Medical University, Guangzhou, Guangdong 510515, China)

机构地区：[1]南方医科大学公共卫生学院病原生物学系,广州510515

出　　处：《寄生虫与医学昆虫学报》2017年第4期257-265,共9页Acta Parasitologica et Medica Entomologica Sinica

基　　金：国家自然科学基金项目(No.31630011);广东省科技计划项目(No.2013B021800042)

摘　　要：蚊媒病是严重的公共卫生问题,遗传控制策略用于蚊虫的控制,它具有种特异性、环境友好、创新性等特点,本文对遗传控制策略的目标、分类及实际应用进展等进行了概述。Genetic engineering techniques are bringing new promise approaches in controlling mosquitoand mosquito borne pathogens. Two genetic control strategies are currently involved as either to suppress target populations or to introduce a harm-reducing novel trait. Self-limiting strategies had been proved with limited persistence, whereas self-sustaining strategies intended to persist indefinitely in the target population and bring high risk to invade un-targeting populations. The field trials have been shown completed and ongoing efforts on the genetic engineer mosquitoes were still carried out due to refractory and/or suppressing factors.

关 键 词：蚊 消除不育技术 HEG WOLBACHIA 抗性昆虫 遗传控制 

分 类 号：R184.3[医药卫生—流行病学]