白兔模型中肛门病术后创面边缘形态对愈合速度的影响研究  

Influence of wound edge shape on healing after anal operation: A rabbit model

作　　者：罗京艺[1] 李克明 马春花[1] 彭书芹[1] Luo Jingyi;Li Keming;Ma Chunhua;Peng Shuqin.(Department of Anorectal Surgery, Liaocheng Second People＇s Hospital, Liaocheng, Shandong, 252601, China)

机构地区：[1]聊城市第二人民医院,山东聊城252601

出　　处：《结直肠肛门外科》2018年第2期152-155,共4页Journal of Colorectal & Anal Surgery

摘　　要：目的观察创面边缘形态对肛门病术后白兔模型创面愈合的影响。方法制备肛门病术后创面的白兔模型,将创缘与创面呈角为90~°的创面归入"直切组",将创缘与创面呈角为135~°的创面归入"斜切组"。分别于造模后第3 d、7 d、10 d、14 d、18 d切取创面肉芽组织进行分析,观察病理变化。结果在造模后第7 d、10 d、14 d,斜切组创面闭合指数均高于直切组,差异均有统计学意义(均P<0.05)。在造模后第3 d、7 d,斜切组创面的毛细血管数量及成纤维细胞数量均较直切组多,差异均有统计学意义(均P<0.05)。在造模后第7 d、10 d、14 d,斜切组创面中的炎性细胞情况大体优于同期直切组。结论对于肛门病术后创面而言,改变肛门部创面边缘的形态(将创缘与创面角度由90~°增加到135~°),可以减轻创面炎性反应,加速创面的愈合。Objective To study the influence of wound edge shape on healing after anal operation in a rabbit model. Methods The model was built in albino rabbits. The angle of incision in the vertical incision group is 90° between the wound surface and edge,and the angle in the oblique incision group is 135°. The granulation tissue was analyzed on the 3 rd, 7 th, 10 th, 14 th, 18 thdays after modeling and the pathological changes was observed. Results On the 7 th, 10 th, and14 thday after modeling, the wound-closed index was higher in the oblique incision group than in the vertical incision group（all P 〈 0.05）. On the 3 rdand 7 thday after modeling, there were more blood capillaries and mechanocytes in the wound in the oblique incision group than in the vertical incision group（all P 〈0.05）. On the 7 th, 10 th, and 14 thday after modeling, the situation of inflammatory cells in the oblique incision group was in general better than in the vertical incision group. Conclusion Changing the wound edge shape by changing the angle between the sound surface and edge from 90° to 135° could relieve inflammatory reaction and promote wound healing.

关 键 词：创面边缘 肛门病术后 创面闭合指数 毛细血管 成纤维细胞 

分 类 号：R657.1[医药卫生—外科学]