瓜蒌薤白半夏汤加减治疗痰瘀阻络型缺血性中风急性期68例  

Sixty-Eight Cases of Acute Stage of Syndrome of Phlegm and Blood Stasis Blocking Meridians Treated with Modified Trichosanthes and Chinese Chive and Pinellia Decoction

作　　者：赵丽敏 ZHAO Li-min(Xinzheng TCM Hospital, Xinzheng, Henan, China ,451100)

机构地区：[1]新郑市中医院,河南新郑451100

出　　处：《河南中医》2018年第4期514-517,共4页Henan Traditional Chinese Medicine

基　　金：河南省科技攻关计划项目(编号:092102310010)

摘　　要：目的:观察瓜蒌薤白半夏汤加减治疗痰瘀阻络型缺血性中风急性期的临床疗效。方法:将136例痰瘀阻络型缺血性中风急性期患者随机分为对照组和观察组,每组各68例。对照组予常规西药治疗,观察组在对照组的基础上联合瓜蒌薤白半夏汤。观察两组患者的临床疗效,比较两组患者治疗前后神经功能缺损评分、临床症状并发症发生率及纤维蛋白原(fibrinogen,FIB)、同型半胱氨酸(homocysteine,Hcy)、丙氨酸氨基转移酶(alanine transaminase,ALT)及血红蛋白(hemoglobin,HGB)变化情况。结果:对照组有效率为82.35%,观察组有效率为94.12%,两组患者临床疗效比较,差异具有统计学意义(P<0.05)。两组患者治疗后NHISS、ADL评分和Hcy、FIB水平较治疗前下降,QLI评分升高,观察组治疗后上述指标较对照组改善显著,差异均有统计学意义(P<0.05)。两组治疗后临床症状并发症发生率较治疗前显著下降,且观察组低于对照组,差异具有统计学意义(P<0.05)。两组治疗前后ALT、HGB比较,差异无统计学意义(P>0.05),FIB、Hcy治疗后较治疗前显著下降,观察组治疗后FIB、Hcy低于对照组,差异均有统计学意义(P<0.05)。结论:瓜蒌薤白半夏汤加减能改善痰瘀阻络型缺血性中风急性期临床症状,提高患者生存质量和日常生活能力。Objective：To observe the clinical curative effect of Modified Trichosanthes and Chinese Chive and Pinellia Decoction on acute stage of syndrome of phlegm and blood stasis blocking meridians.Methods：One hundred and thirty-six patients with acute stage of syndrome of phlegm and blood stasis blocking meridians were randomly divided into the treatment group and the control group,with 68 cases in each group.The ones in the control group were given routine Western medicine treatment,while the ones in the treatment group were added Trichosanthes and Chinese Chive and Pinellia Decoction based on the treatment of the control group.Then the clinical curative effects of the two groups were observed.The changes of the two groups＇ neurological deficit scores,clinical symptoms and the incidence rates,fibrinogen（FIB）,homocysteine（Hcy）,alanine aminotransferase（ALT） and hemoglobin（HGB） before and after the treatment were compared.Results：The effective rate of the control group was 82.35%,while that of the observation group was 94.12%.The difference between the two groups was statistically significant（P〈0.05）.After the treatment,the two groups＇ NHISS,ADL scores and Hcy,FIB decreased significantly compared with before the treatment,QLI scores increased significantly,the above indicators of the observation group after the treatment were significantly improved compared with the control group,and all the differences were statistically significant（P〈0.05）.The incidence of complications after the treatment in the two groups was significantly decreased before the treatment,and the observation group was lower than the control group,the difference was statistically significant（P〈0.05）.There was no significant difference in the ALT and HGB between the two groups before and after the treatment（P〈0.05）.FIB and Hcy decreased significantly after the treatment compared with those before the treatment.The FIB and Hcy in the observation group were lower than those in the control group,and all the d

关 键 词：缺血性中风 急性期 瓜蒌薤白半夏汤 痰瘀阻络证 张仲景 《金匮要略》 

分 类 号：R255.2[医药卫生—中医内科学]