兴安升麻化学成分的分离与鉴定  

Isolation and identification of the chemical constituents from the rhizomes of Cimicifuga dahurica(Turcz.) Maxim.

作　　者：周万荣 陆庆云 吕重宁 张昕[1] 秦汝兰[2] 路金才[1] ZHOU Wanrong;LU Qingyun;LV Chongning;ZHANG Xin;QIN Rulan;LU Jincai(School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;College of Pharmacy and Food Sciences, Tonghua Normal University, Tonghua 134002, China)

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]通化师范学院制药与食品科学学院,吉林通化134002

出　　处：《沈阳药科大学学报》2018年第4期269-273,共5页Journal of Shenyang Pharmaceutical University

基　　金：辽宁省教育厅高校基本科研项目(2017LQN09);沈阳药科大学大学生创新创业训练计划项目(201610163052)

摘　　要：目的对兴安升麻(Cimicifuga dahurica(Turcz.)Maxim.)的化学成分进行研究。方法应用硅胶、ODS柱色谱与制备高效液相相结合的方法对兴安升麻正丁醇层及水层进行分离纯化,并通过理化性质与核磁共振波谱数据鉴定化合物的结构。结果从兴安升麻正丁醇层及水层提取物中分离鉴定了10个单体化合物,分别为咖啡酸甲酯(methyl caffeate,1)、咖啡酸乙酯(ethyl caffeate,2)、对羟基苯乙酸(4-hydroxyphenylacetic acid,3)、肉桂酸(cinnamic acid,4)、对羟基桂皮酸(p-hydroxyl cinnamic acid,5)、cimidahurine(6)、rubraside A(7)、25-O-乙酰基升麻醇-3-O-β-D-木糖苷(25-O-acetyl-cimigenol-3-O-β-D-xylopyranoside,8)、25-脱水升麻醇-3-O-β-D-木糖苷(25-anhydrocimigenol-3-O-β-D-xylopyranoside,9)、cimiracemoside E(10)。结论化合物1-5,7为首次从升麻属中分离得到。Objective To study the chemical constituents of Cimicifuga dahurica（ Turcz.） M axim. Methods The compounds w ere isolated and purified by chromatographic methods,such as silica gel,ODS column chromatography and HPLC. The structures w ere identified by measuring the physicochemical property and spectral data. Results Ten compounds w ere isolated and identified as methyl caffeate（ 1）,ethyl caffeate（ 2）,4-hydroxyphenylacetic acid（ 3）,cinnamic acid（ 4）,p-hydroxyl cinnamic acid（ 5）,rubraside A（ 6）,cimidahurine（ 7）, 25-acetylcimigenol-3-O-β-D-xylopysanoside（ 8）, 25-anhydrocimigenol-3-O-β-D-xylopyranoside（ 9） and cimiracemoside E（ 10）. Conclusions Compounds 1-5,7 are isolated from Cimicifuga genus for the first time.

关 键 词：兴安升麻 化学成分 结构鉴定 

分 类 号：R28[医药卫生—中药学]