内质网应激在酒精诱导的中枢神经毒性中的作用  

The role of endoplasmic reticulum stress in the central neurotoxicity induced by alcohol

作　　者：崔佳慧 吴英良[1] 左代英[1] CUI Jiahui;WU Yingliang;ZUO Daiying(Life Science and Biopharmaceutical School, Shenyang Pharmaceutical University, Shenyang 110016, China)

机构地区：[1]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2018年第4期329-334,共6页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81403023);辽宁省高等学校优秀人才支持计划(LJQ2015111)

摘　　要：目的综述内质网应激(endoplasmic reticulum stress,ERS)在酒精诱导的中枢神经毒性中的作用。方法通过查阅相关文献对其进行归纳总结。从ERS诱导细胞凋亡的通路、酒精诱导ERS的机制、ERS在酒精所致脑损伤中与细胞凋亡、自噬和炎症反应的关系等几个方面进行介绍。结果系统总结了ERS诱导细胞凋亡的通路;酒精诱导ERS的作用机制与乙醛加合物的存在、钙离子的稳态和氧化应激等有关;酒精诱导ERS后可引起细胞凋亡、自噬和炎症反应。结论 ERS在酒精诱导中枢神经毒性中发挥重要作用。Objective To review the role of endoplasmic reticulum（ ERS） in alcohol-induced central nervous system toxicity. Methods According to the relevant literatures,w e summarized ERS-induced apoptosis pathw ay,the mechanism of alcohol-induced ERS,the relationship betw een ERS and cell apoptosis,autophagy and inflammatory response after alcohol-induced brain injury. Results The pathw ays of ERS-induced apoptosis w ere systematically summarized. The mechanisms of alcohol-induced ERS are related to the presence of acetaldehyde adduct,the steady state of calcium ion and oxidative stress. Alcohol-induced ERS can cause cell apoptosis,autophagy and inflammatory response. Conclusions ERS plays an important role in alcohol-induced central nervous system toxicity.

关 键 词：酒精 内质网应激 神经毒性 

分 类 号：R96[医药卫生—药理学]