产前胎儿侧脑室扩张合并异常及其临床意义  

The types of abnormalities and clinical significance in fetus with non-isolated cerebral ventriculomegaly

作　　者：彭奕贤 黄启涛[1] 陈翠华[1] 刘思平[1] 常清贤[1] PENG Yixian;HUANG Qitao;CHEN Cuihua;LIU Siping;CHANG Qingxian(Department of Obstetrics and Gyne- cology, Nanfang Hospital of Southern Medical University, Guang Zhou 510515, China)

机构地区：[1]南方医科大学南方医院妇产科,广州510515

出　　处：《实用医学杂志》2018年第8期1305-1307,1312,共4页The Journal of Practical Medicine

基　　金：2014年度广州市科技计划(编号:2014Y2-00115)

摘　　要：目的分析非孤立性侧脑室扩张合并异常及不同侧脑室宽度间合并异常的差异及其临床意义。方法收集自2010年3月至2016年12月,因产前超声提示"胎儿侧脑室扩张"的到南方医院高危产科就诊,并接受产前诊断的单胎妊娠孕妇298例,其中孤立性侧脑室扩张109例,非孤立性侧脑室扩张189例。将其按侧脑室宽度分别分为轻度组(10.0～11.9 mm)、中度组(12.0～14.9 mm)、重度组(≥15.0mm)。结果 (1)非孤立性侧脑室扩张最常合并神经系统发育异常(37.30%,94/252);其次为超声软指标异常,占(27.78%,70/252)。(2)轻度组最常合并超声软标志异常(44.76%,47/105),其次为其他超声指标(18.10%,19/105);中度组合并中枢神经系统异常发生率较高(45.16%,42/93),其次为超声软指标异常(21.51%,20/93);重度组多合并中枢神经系统异常(62.96%,34/54),其次为心血管系统异常(14.81%,8/54)。(3)不同侧脑室宽度的非孤立性侧脑室扩张患儿合并神经系统、超声软指标异常间存在差异,差异有统计学意义(P<0.001)。结论产前超声发现侧脑室扩张应仔细检查胎儿各系统是否存在其他异常,以判断胎儿预后及是否需要采取干预措施。不同侧脑室宽度合并畸形及预后间存在差异。Objective To analysis the common abnormalities in fetus with ventriculomegaly and clinicalsignificance. Methods Collected from March 2010 to December 2016,298 cases of pregnant women whose fetuswith ventriculomegaly and accepted the prenatal diagnosis of pregnancy,including 109 cases of isolated cerebralventriculomegaly（IVM）,and 189 cases of non-isolated cerebral ventriculomegaly（NIVM）. They were divided intomild groups（10.0-11.9 mm）,moderate group（12.0-14.9 mm）and severe group（≥15.0 mm）according to thewidth of the lateral ventricle. Results（1）The most common abnormality of the NIVM were neurodevelopmentalsystem（37.30%,94/252）;The second was ultrasonic soft index（27.78%,70/252）.（2）The most frequent combi-nation in mild group was ultrasonographic soft mark anomalies（44.76%,47/105）,followed by other ultrasonic indi-cators（18.10%,19/105）. The abnormal incidence of central nervous system was higher in middle group（45.16%,42/93）,followed by ultrasonic soft index abnormality（21.51%,20/93）. The abnormality of the central nervous sys-tem was 62.96%（34/54）in severe group,followed by an abnormal（14.81%,8/54）.（3）There was a difference inthe nervous system and the ultrasonic-soft indicator between the non-isolated lateral ventricle dilation with differentlateral ventricle widths（P〈0.001）. There was no difference in cardiovascular abnormalities. Conclusion Prena-tal ultrasound revealed that fetus with cerebral ventriculomegaly should carefully examine whether other abnormali-ties existed to determine the prognosis of the fetus and whether intervention should be taken. There was a differencebetween the different types of lateral ventricle and the prognosis.

关 键 词：非孤立性 侧脑室扩张 合并异常 

分 类 号：R714.5[医药卫生—妇产科学]