线粒体泛素连接酶在带状疱疹后遗神经痛患者脑脊液中的表达及意义  

Expression of MITOL in the cerebrospinal fluid of patients with postherpetic neuralgia and its clinical significance

作　　者：涂涛[1] 叶玙 董蜀华[1] TU Tao;YE Yu;DONG Shuhua(Department of Anesthesiology, The First Affiliated Hospital of Cheng- du Medical College, Chengdu 610500, China)

机构地区：[1]成都医学院第一附属医院麻醉科,成都610500

出　　处：《实用医学杂志》2018年第8期1320-1322,1326,共4页The Journal of Practical Medicine

基　　金：四川省应用基础研究计划项目(编号:2014JY0123)

摘　　要：目的探讨线粒体泛素连接酶(MITOL)在带状疱疹后遗神经痛(PHN)患者脑脊液中的表达及临床意义。方法选取2015年8月到2016年12月诊治的带状疱疹后遗神经痛患者45例作为PHN组,以同期年龄、性别相匹配的38例腰椎间盘突出症患者为IDH组。通过ELISA及蛋白印迹法检测脑脊液MITOL表达。分析PHN组患者脑脊液MITOL表达与其临床特征的关系。结果 PHN组脑脊液MITOL表达明显高于IDH组,差异有统计学意义(P<0.05);其表达与患者年龄及疼痛程度比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示年龄(OR值2.717)和疼痛程度(OR值3.042)是PHN发生的危险因素。结论 MI-TOL在带状疱疹后遗神经痛患者脑脊液中表达升高,其可能与患者年龄和疼痛程度有关。Objective To explore the expression of mitochondrial ubiquitin ligase（MITOL）in the cere-brospinal fluid from patients with postherpetic neuralgia（PHN）. Methods A total of 45 patients who were diag-nosed with PHN in our hospital from August 2015 to December 2016 were enrolled in this study,and 38 gender-and age-matched patients with lumbar disc herniation were recruited as IDH group. The MITOL was measured bythe ELISA and Western blot methods. The correlation between the expression of MITOL in cerebrospinal fluids andclinical characteristics of patients with PHN was evaluated. Results The expression of MITOL was significantly in-creased in cerebrospinal fluids of patients with PHN compared with IDH,and it was associated with age and thepain intensity（P〈0.05）. Logistic regression analysis showed age（OR,2.717）and the pain intensity（OR,3.042）were risk factors for PHN. Conclusions The expression of MITOL is significantly increased in the cerebrospinalfluid of PHN,which may be associated with age and pain intensity.

关 键 词：带状疱疹后遗神经痛 线粒体泛素连接酶 脑脊液 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]