健脾祛痰法治疗冠心病心绞痛的临床观察及神经调节机制（英文）  

Clinical observation and neural regulatory mechanism in the treatment of patients with angina pectoris with Jianpi Qutan method

作　　者：刘悦[1] 张帆[2] 王洋[2] 孔德昭[1] 尹妮[2] 高晓宇[2] 陈莹[1] 张哲[2] 张艳[2] 杨关林[1] LIU Yuel;ZHANG Fan;WANG Yang;KONG De-zhao;YIN Ni;GAO Xiao-yu;CHEN Ying;ZHANG Zhe;ZHANG Yan;YANG Guan-lin(Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《中华中医药杂志》2018年第5期2198-2202,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：National Key Basic Research Program of China(973 Program)(No.2013CB531704)~~

摘　　要：目的:探讨健脾祛痰法在缓解冠心病心绞痛的疗效及神经调节机制,为冠心病临床用药选择及脏象理论的创新提供临床依据。方法:采用多中心、随机、盲法、安慰剂对照的方法收集中国东北部240例冠心病心绞痛患者,分层区组随机分为3组,在基础治疗上,治疗1组给予益气健脾祛痰和血中药颗粒剂,治疗2组给予益气健脾祛痰化瘀中药颗粒剂,对照组给予中药颗粒安慰剂,疗程12周。第0、4、12周分别观察3组临床疗效及5-羟色胺(5-HT)、去甲肾上腺素(NE)、乙酰胆碱(Ach)含量的变化。结果:治疗12周后,治疗组患者心绞痛症状及中医证候明显改善(P<0.05),5-HT、NE、Ach水平与治疗前比较均显著性下降(P<0.05)。结论:健脾祛痰法治疗冠心病心绞痛临床疗效显著,能够对抗神经递质水平的失衡,这可能是从脾论治冠心病心绞痛的作用机制之一。Objective： To investigate the therapeutic effect and neural regulatory mechanism in the treatment of patients with angina pectoris with Jianpi Qutan method, which will provide clinical evidence for the choice of clinical medication and the innovation of viscera theory. Methods： This is a north-east Chinese, multi-center, multi-blinded, placebo-controlled and superiority randomized trial. A total of 240 patients with stable angina pectoris will be randomly assigned to three groups： two treatment groups and a control group. The treatment groups will receive Chinese herbal medicine consisting of Yiqi Jianpi and Qutan Hexue Granule and Yiqi Jianpi and Qutan Huayu Granule, respectively, and conventional medicine. The control group will receive placebo medicine in addition to conventional medicine. All 3 groups will undergo a 12-week treatment. Three visits in sum will be scheduled for each subject： visit each in week 0, week 4, week 12. The therapeutic effects and the changes of 5-HT, NE and Ach were observed in three groups. Results： After 12 weeks treatment, the treatment group can relieve angina pectoris and improve the syndrome of traditional Chinese medicine（P〈0.05）. The changes of 5-HT, NE and Ach were significantly decreased after treatment（P〈0.05）. Conclusion： The therapeutic effects in the treatment of patients with angina pectoris with Jianpi Qutan are significant. It can modulate the unbalance of neurotransmitters, of which may be one mechanism of the treatment of patients with angina pectoris based on the spleen.

关 键 词：冠心病心绞痛 健脾祛痰法 神经递质 5-羟色胺 去甲肾上腺素 乙酰胆碱 

分 类 号：R259[医药卫生—中西医结合]