紫堇的化学成分研究  

Chemical constituents from whole herbs of Corydalis edulis

作　　者：晁凌会 彭治添 任易[1] 张云封[1] 孙慧[1] 陈孝男 姚会娜 郑姣[1] 屠鹏飞[1] 张媛[1] 李军[1] CHAO Ling-hui;PENG Zhi-tian;REN Yi;ZHANG Yun-feng;SUN Hui;CHEN Xiao-nan;YAO Hui-na;ZHENG Jiao;TU Peng-fei;ZHANG Yuan;LI Jun(Modem Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China)

机构地区：[1]北京中医药大学中药学院中药现代研究中心,北京100029

出　　处：《中草药》2018年第7期1508-1512,共5页Chinese Traditional and Herbal Drugs

基　　金：教育部新世纪优秀人才支持计划资助项目(NCET-13-0693);北京中医药大学自主课题(2017-JYB-XS-069)

摘　　要：目的研究紫堇Corydalis edulis全草的化学成分。方法采用硅胶、Sephadex LH-20、ODS柱色谱和半制备HPLC等色谱方法分离纯化,结合其理化性质和MS、NMR等波谱学数据鉴定化合物的结构。结果从紫堇乙醇提取物的正丁醇萃取部位分离鉴定了15个化合物,分别鉴定为6,7-亚甲二氧基二氢异香豆素(1)、oxohydrastinine(2)、6,7-dimethoyisoquinolin-1(2H)-one(3)、6,7-methylenedioxy-1(2H)-isoquinolinone(4)、(+)-丁香树脂素(5)、梣皮树脂醇(6)、红景天苷(7)、1-(2-羟基苄基)-β-D-吡喃葡萄糖苷(8)、淫羊藿次苷D_2(9)、水杨苷(10)、淫羊藿次苷F_2(11)、淫羊藿次苷B_2(12)、烟酰胺(13)、邻苯二酚(14)和5-羟基-2-羟甲基吡啶(15)。结论化合物1为新天然产物,化合物3、5~12、14和15为首次从紫堇属植物中分离得到,化合物2、4和13为首次从紫堇中分离得到。Objective To investigate the chemical constituents from the herbs of Corydalis edulis. Methods The compounds were isolated and purified by various column chromatographies, and their structures were identified by physiochemical properties and spectroscopic data. Results Fifteen compounds were isolated from the n-Bu OH layer of Et OH extract of the herbs of C. edulis. and identified as 6,7-methylenedioxydihydroisocoumarin（1）, oxohydrastinine（2）, 6,7-dimethoyisoquinolin-1（2 H）-one（3）, 6,7-methylenedioxy-1（2 H）-isoquinolinone（4）,（＋）-syringaresinol（5）,（＋）-medioresinol（6）, salidroside（7）, isosalicin（8）, icariside D2（9）, salicin（10）, icariside F2（11）, icariside B2（12）, nicotinamide（13）, pyrocatechol（14）, and 5-hydroxyl-2-hydroxymethylpyridine（15）, respectively. Conclusion Compound 1 is a new natural product. Compounds 3, 5—12, 14, and 15 were isolated from Corydalisspecies for the first time. Compounds 2, 4, and 13 were firstly obtained from C. edulis.

关 键 词：紫堇 喹诺酮 木脂素 6 7-亚甲二氧基二氢异香豆素 6 7-dimethoyisoquinolin-1(2H)-one 

分 类 号：R284.1[医药卫生—中药学]