补阳还五汤的研究现状及其新药创制关键技术  

Current research situation of Buyang Huanwu Decoction and its development of new medical invention

作　　者：肖美凤[1,2,3] 刘金玲 杨岩涛[1,2,3] 刘文龙 周逸群[1,2,3] 贺福元 邓凯文[3,4] XIAO Mei-feng;LIU Jin-ling;YANG Yan-tao;LIU Wen-long;ZHOU Yi-qun;HE Fu-yuan;DENG Kai-wen(College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China;Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [3]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208 [4]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中草药》2018年第7期1688-1694,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81573691);湖南省自然科学基金资助项目(2016JJ405);湖南省中医药科研计划(2015171);湖南省科技厅重点实验室建设资助项目(2016TP1017)

摘　　要：补阳还五汤是目前治疗缺血性脑卒中疗效公认的著名方剂,该方每年有500余篇文献报道,包括药材资源、物质基础、药物制剂、药理作用、临床配伍应用及剂型改革等各方面,研究范围宽广而精深。但该方成分复杂,目前的网络药理拓扑学方法也很难阐明该方的物质基础及药理学作用机制。系统梳理补阳还五汤近10年相关研究工作,归纳总结药学、药理毒理学的研究概况,提出目前研究存在的问题及作为组分中药或天然复方药物创制研究亟待解决的关键问题;同时结合中药超分子"印迹模板"自主作用规律和化学定量网络谱学的研究,与目前主要治疗缺血性脑卒中药物的结构进行比较,拟对其物质基础、效应成分与作用靶点关联等关键技术进行探讨,为进一步开发出新组分中药或天然复方药物奠定基础。Buyang Huanwu Decoction（BHD） is a famous prescription for treating cerebral ischemia stroke with qi deficiency and blood stasis syndrome. More than 500 pieces of papers were reported about this prescription each year, including the medicinal resources, material bases, pharmaceutical, pharmacological effects, clinical application, preparation reform and so on, which showed the prescription research was broad and profound. Due to the complex constituents of this prescription, currently the network pharmacologic topologic method is difficult to illuminate the material basic and pharmacological mechanism of BHD. This paper has systematically sorted and analyzed BHD related research work for nearly ten years, mainly summarized pharmacy, pharmacology, and toxicology, thereby to put forward the present key problems to be solved immediately for creating a constituent Chinese medicine or natural compound medicine. Meanwhile, combined with the previous researches of quantitative network chromatopharmology, compared with the present medicine-marketed molecular structure main in treatment of ischemic stroke,intends to discuses critical technical problems of the material bases, the connection affirmation of effective ingredients and targets etc, in order to find out solution strategy and to lay a foundation for further development of a new constituent Chinese medicine or natural compound medicine.

关 键 词：补阳还五汤 物质基础 作用机制 网络药理学 超分子 组分中药 天然复方药物 

分 类 号：R285[医药卫生—中药学]