裸花紫珠叶中1个新的环烯醚萜苷  

A new iridoid glycoside from leaves of Callicarpa nudiflora

作　　者：马员宇 付辉政 潘蕾 王杰 周志强 黄波 罗跃华 MA Yuan-yu;FU Hui-zheng;PAN Lei;WANG Jie;ZHOU Zhi-qiang;HUANG Bo;LUO Yue-hua(Jiangxi Center for Drug Evaluation, Nanchang 330006, China;Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality, Nanchang 330029, China)

机构地区：[1]南昌大学药学院,江西南昌330006 [2]江西省药品检验检测研究院江西省药品与医疗器械质量工程技术研究中心,江西南昌330029

出　　处：《中草药》2018年第8期1746-1750,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81373955);江西省自然科学基金资助项目(20142BAB205085);校级创新基金(CX2016291)

摘　　要：目的研究裸花紫珠Callicarpa nudiflora的化学成分。方法利用硅胶、MPLC柱色谱、高效制备液相色谱等色谱方法进行分离纯化,根据理化常数测定及波谱数据分析鉴定化合物结构。结果从裸花紫珠叶80%乙醇提取物中分离得到5个化合物,分别鉴定为6′-O-咖啡酰基益母草苷(1)、木犀草素(2)、5,4′-二羟基-3,7,3′-三甲氧基黄酮(3)、木犀草素-4′-O-(6″-E-咖啡酰)-β-D-吡喃葡萄糖苷(4)、2α,3α,19α,23-四羟基-12-烯-28-乌苏酸(5)。结论化合物1为新化合物,命名为裸花紫珠苷A1。Objective To study the chemical constituents of the leaves of Callicarpa nudiflora. Methods The chemical constituents were isolated and purified by column chromatography on silica gel, MPLC, and PHPLC. Their structures were elucidated on the basis of physicochemical properties and spectroscopic analysis. Results Five compounds were isolated from the leaves of C. nudiflora and elucidated as 6′-O-caffeoyl-ajugol（1）, luteolin（2）, 5,4′-dihydroxy-3,7,3′-trimethoxyflavone（3）, luteolin-4′-O-（6′′-E-caffeoyl）-β-D-glucopyranoside（4）, and 2α,3α,19α,23-tetrahydroxyurs-12-en-28-ursolic acid（5）. Conclusion Compound 1 is a new compound named nudifloside A1.

关 键 词：裸花紫珠 环烯醚萜苷 6′-O-咖啡酰基益母草苷 裸花紫珠苷A1 木犀草素 5 4′-二羟基-3 7 3′-三甲氧基黄酮 

分 类 号：R284.1[医药卫生—中药学]