半夏-厚朴药对抗肿瘤功效物质基础及作用机制研究新思路  

New thoughts on antitumor functional material base and mechanism of Pinelliae Rhizoma-Magnoliae Officinalis Cortex couplet medicines

作　　者：袁海建[1] 李国银 姜俊[1] 陈靖靖[1] 贾晓斌[2] 封亮[2] 刘玉梅 YUAN Hai-jian;LI Guo-yin;JIANG Jun;CHEN Jing-jing;JIA Xiao-bin;FENG Liang;LIU Yu-mei(Taizhou Polytechnic College, Taizhou 225300, China;Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China)

机构地区：[1]泰州职业技术学院,江苏泰州225300 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028

出　　处：《中草药》2018年第8期1924-1931,共8页Chinese Traditional and Herbal Drugs

基　　金：泰州市科技支撑计划项目资助(TS201721);泰州职业技术学院科研项目资助(TZYKY-17-25);泰州职业技术学院创新型科研团队资助项目(TZYTD-16-1);江苏省"青蓝工程"资助项目(2016);江苏省卫生计生委科研课题(JZ201607)

摘　　要：中药是中医临床用药的实践产物,由于中药化学成分和人体的复杂性,导致功效物质基础及其机制研究面临困境。对半夏、厚朴单味药材化学成分、抗肿瘤功效物质基础及相关机制进行总结分析,找出存在问题,并提出代谢组学结合网络药理学研究半夏-厚朴药对的思路与方法,以期更好地阐释半夏-厚朴药对抗肿瘤功效物质基础及作用机制、揭示药对配伍规律的科学内涵,为进一步深入研究复方配伍规律提供理论基础和思路建议。Chinese materia medica（CMM） is the product of clinical practice of traditional Chinese medicine. Due to the complexity of the chemical composition of CMM and human body, the functional material base and its mechanism researches were facing a dilemma. In this paper, the chemical composition, antitumor material base, and related mechanism of Pinellia Rhizoma and Magnolia Officinalis Cortex were summarized and analyzed, and the existing problems were found. In order to better elucidate the functional material base and mechanism of the antitumor effects of Pinellia Rhizoma-Mangnolia Officinalis Cortex couplet medicines and reveal the scientific connotation of couplet medicines compatibility, the research thoughts of metabonomics combined with network pharmacology were proposed. With a view to providing theoretical basis and suggestion for the further research on the compound compatibility law.

关 键 词：半夏-厚朴药对 抗肿瘤 功效物质基础 作用机制 研究思路 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]