复殖亚纲线粒体基因组特征分析及其应用进展  

Analysis of Digenea Mitochondrial Genome Characteristics and Its Application Progress

作　　者：聂宗恒 白俊[1] 许姝歆 汪雁[2,5] 朱春潮[1,2] 王洪举 卓玛央金 刘彩 马兵成 石林波[1,2] 张小燕[1,2] 洪芬芳[2] 王一帆 闵卫平 邹节新[1,2,5] 周宪民[2,4,5] Nie Zongheng;Bai Jun;Xu Shuxin;Wang Yan;Zhu Chunchao;Wang Hongju;Zhuoma Yangjin;Liu Cai;Ma Bingcheng;Shi Linbo;Zhang Xiaoyan;Hong Fenfang;Wang Yifan;Min Weiping;Zou Jiexin;Zhou Xianmin(Department of Human Parasitology, School of Basic Medical Sciences, Nanchang University, Nanchang, 330006;Research Lab of Freshwater Crus- tacean Decapoda and Paragonimus, School of Basic Medical Sciences, Nanchang University, Nanchang, 330006;Center for Disease Control and Prevention of Linzhi, Linzhi, 860000;Institute of Pathogen Biology, Jiangxi Academy of Medical Sciences, Nanchang, 330006;Ministry Education Key Laboratory of Poyang Lake Environment and Resource Utilization, Nanchang University, Nanchang, 330047)

机构地区：[1]南昌大学基础医学院人体寄生虫学教研室,南昌330006 [2]南昌大学基础医学院淡水十足目甲壳动物与并殖吸虫研究室,南昌330006 [3]西藏林芝地区疾病预防控制中心,林芝860000 [4]江西省医学科学院病原生物学研究所,南昌330006 [5]南昌大学鄱阳湖环境与资源利用教育部重点实验室,南昌330047

出　　处：《基因组学与应用生物学》2018年第4期1413-1422,共10页Genomics and Applied Biology

基　　金：国家自然科学基金项目(81260257;81160207;31460156;31560179);南昌大学研究生创新专项资金(CX2016280)共同资助

摘　　要：日本血吸虫（Schistosoma japonicum）等具有重要流行病学意义的寄生虫,在分类学上均隶属于吸虫纲（Trematoda）的复殖亚纲（Digenea）。目前,对复殖亚纲成虫及虫卵形态、生活史及其防治的研究已较为深入,分子生物学手段也已逐渐应用于人体寄生虫学研究领域,但在基因组学角度对该类群遗传特征的系统性研究尚不多见。自首条人类线粒体基因组公布以来,线粒体基因组凭借其母系遗传、缺乏重组、进化速率快等特点,逐渐成为遗传学及动物进化生物学等领域的研究热点。当前,Gen Bank已公布复殖亚纲36个物种的线粒体全基因组数据。本综述在总结各类群研究进展的基础上,对已有线粒体基因组的碱基偏好、基因组成及排列、密码子利用、t RNA二级结构及非编码区等方面进行了比较分析。综合当前研究进展发现,基因排列等特征与系统发生的关联性研究较为匮乏,线粒体全基因组数据严重不足,数据积累及深度挖掘仍是当前的重要基础性工作。Parasites such as Schistosom a japonicum, which have important epidemiologic significance, are subclassically classified as Digenea of Trematoda. At present, the research on the morphology, life history,prevention and control of adult and larvae of Digenea has been carried out deeply. Molecular biology has also been applied in the field of human parasitology but the systematic research of the genetic characteristics of the group at the perspective of genomics is still rare. Since the release of the first human mitochondrial genome, the mitochondrial genome has gradually become a hotspot in the fields of genetics and animal evolutionary biology by virtue of its maternal inheritance, lack of recombination and fast evolution rate. For the moment, Gen Bank has released mitochondrial genomic data of 36 species of Digenea. On the basis of summarizing the research progress of each group, this review made a comparative analysis of the base preference, gene composition and arrangement,codon utilization, t RNA secondary structure and noncoding region of the existing mitochondrial genome. Based on the current research progress, it can be found that the correlation between gene arrangement and phylogeny is scarce, and the whole genome data of mitochondria are seriously deficient. Data accumulation and depth excavation are still the important basic work at present.

关 键 词：复殖亚纲 线粒体基因组 系统发育 基因重排 

分 类 号：R383.24[医药卫生—医学寄生虫学]