糖皮质激素对AECOPD患者血清TNF-α和肺功能的影响研究  

The effect of glucocorticoid on serum TNF-α and lung function in patients with AECOPD

作　　者：周丽 李兴明[2] 王宪刚[2] 张永 ZHOU Li;LI Xing-ming;WANG Xian-gang;et al(Southwest Medical University School of Medicine, Luzhou, Sichuan 646000, Chin)

机构地区：[1]西南医科大学临床医学院,四川省泸州市646000 [2]四川省内江市第一人民医院呼吸内科,641000

出　　处：《临床合理用药杂志》2018年第11期10-11,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析糖皮质激素对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清肿瘤坏死因子(TNF-α)和肺功能的影响。方法选取医院收治的AECOPD患者84例为观察组,同期门诊体检证实的健康志愿者60例为对照组,观察组给予静脉应用糖皮质激素1周,并在治疗前和治疗1周后测定肺功能及血清TNF-α浓度与对照组进行比较。结果治疗前观察组TNF-α、FEV1%分别为[(9.34±5.64)pg/ml、(35.88±19.24)%],治疗1周后分别为[(4.65±4.41)pg/ml,(42.96±23.20)%],治疗前后比较差有统计学意义(P<0.05);治疗1周后,观察组血清TNF-α浓度、FEV1%与对照组比较,差异无统计学意义(P>0.05)。结论经糖皮质激素治疗后AECOPD患者血清TNF-α的水平降低,肺功能得到改善。Objective The effects of glucocorticoids on serum tumor necrosis factor（ TNF-α） and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD） were analyzed. Methods Eighty-four AECOPD patients admitted to the hospital were selected as the observation group. During the same period,60 healthy volunteers confirmed by outpatient physical examination were the control group. The observation group was given glucocorticoid intravenously for 1 week,and the lung function and serum TNF-α concentration were measured before treatment and 1 week after treatment compared with the control group. Results Before treatment,TNF-α and FEV1% in the observation group were[（ 9. 34 ± 5. 64） pg/ml,（ 35. 88 ± 19. 24） % ],respectively. One week after treatment,it was [（ 4. 65 ± 4. 41） pg/ml,（ 42. 96 ± 23. 20） %]. The difference between before and after treatment was statistically significant（ P〈0. 05）. After one week of treatment,there was no significant difference in serum TNF-α concentration and FEV1% between the observation group and the control group（ P〉0. 05）. Conciusion After glucocorticoid treatment,serum TNF-α levels in patients with AECOPD decreased,and lung function improved.

关 键 词：慢性阻塞性肺疾病急性加重期 糖皮质激素 血清肿瘤坏死因子 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]