水族抗痹症药酒动物急性毒性试验  

Acute Toxicity Animal Test of Aquatic Anti-arthralgia Medicinal Liquor

作　　者：臧贵勇[1] 王燕林 罗海燕[1] 刘运敏[1] 潘开昌[1] 吉杨丹[1] 王恒[1] ZANG Gui - yong;WANG Yah - lin;LUO Hai - yah;LIU Yun - min;PAN Kai -chang;JI Yang- dan;WANG Heng(Qiannan Medical College for Nationalities, Duyun, 558013, Guizhou)

机构地区：[1]黔南民族医学高等专科学校,贵州都匀558013

出　　处：《黔南民族医专学报》2018年第1期42-44,共3页Journal of Qiannan Medical College for Nationalities

基　　金：黔南州社会发展(卫生类)科技计划项目[黔南科合社字(2017)74号];黔南民族医学高等专科学校科研基金(QNYZ201713;QNYZ201719)

摘　　要：目的:研究水族抗痹症药酒的急性毒性,确定其安全范围。方法:抗痹症药酒及对照白酒不同浓度小鼠一次灌胃给药,观察7 d内小鼠死亡数,Bliss法测定小鼠的LD_(50)。结果:抗痹症药酒小鼠一次经口给药LD_(50)=29.664ml/kg,LD_(50)的95%可信限为26.452~31.904ml/kg;白酒对照组小鼠一次经口给药LD_(50)=27.222 ml/kg,LD_(50)的95%的可信限=24.194~29.759ml/kg。结论:抗痹症药酒临床建议成人适用量23.4ml/d,服用安全。Objective： To study the acute toxicity of aquatic anti-arthralgia medicinal liquor and determine its safety scope. Methods： Mice with different concentrations of aquatic anti-arthralgia medicinal liquor and controlled liquor were administered intragastrically once a day,and the number of mice died within 7 days was observed. The LD（50） of mice was determined by Bliss method. Result： The one-dose oral administration of aquatic anti-arthralgia medicinal liquor LD（50） was 29.664ml/kg,the 95% confidence limit of LD（50） was26.452 - 31.904ml/kg. In the control group of white wine,one dose administration LD（50） was 27.222ml/kg,the 95% confidence limit of LD（50）= 24.194 - 29.759 ml/kg. Conclusion： The clinical application of aquatic anti-arthralgia medicinal liquor is recommended to be 23.4ml/d for adult use.

关 键 词：抗痹症药酒 急性毒性 LD50 

分 类 号：R296.908[医药卫生—民族医学]