不同年龄冠心病患者临床特点及冠状动脉病变危险因素分析  

Analysis between characteristics and risk factors of coronary heart disease in different ages

作　　者：王亚君 马燚[2] 崔川[2] 李莉[2] WANG Ya-jun,MA Yi,CUI Chuan,et al(North China University of Science and Technology,Tangshan 063000,Chin)

机构地区：[1]华北理工大学研究生学院,河北唐山063000 [2]唐山工人医院心内二科

出　　处：《华北理工大学学报（医学版）》2018年第3期200-204,209,共6页Journal of North China University of Science and Technology：Health Sciences Edition

摘　　要：(1)目的探讨不同年龄冠心病患者临床特点、冠状动脉危险因素与冠状动脉粥样硬化病变程度的关系。(2)方法选取唐山工人医院心内科2016年2月~2017年2月入院后行冠状动脉造影的冠心病患者610例,收集其一般资料及其他临床指标。(3)结果单因素分析中青年组冠心病患者性别、抽烟、饮酒、体质量指数(BMI)、家族史显著高于老年组,而高血压、糖尿病、HDL-C、血浆脂蛋白磷脂酶A2(Lp-PLA2)水平和Gensini评分均低于老年组,差异均有统计学意义。Logistic回归分析显示中青年冠心病冠状动脉病变程度加重的独立危险因素依次为糖尿病、高血压、吸烟、高血脂、家族史、胆固醇(TC),其OR值依次为19.015、16.990、13.971、6.507、6.358、3.500;高密度脂蛋白(HDL-C)为保护性因素,其OR值为0.008;老年冠心病冠状动脉病变程度加重的独立危险因素依次为家族史、饮酒、TC、LpPLA2,其OR值依次为5.421、2.613、1.445、1.009。(4)结论不同年龄冠心病患者的临床特点与危险因素有差异性。中青年冠心病患者主要与糖尿病、高血压、吸烟、家族史、低HDL-C有关;老年冠心病患者与饮酒、Lp-PLA2有关;而家族史、TC可影响任何年龄冠状动脉病变;这些危险因素均可使冠状动脉粥样硬化病变程度增加。Objective To explore the correlation between cardiovascular risk factors and severity of coronary artery disease in patients with different ages.Methods A total of 610 patients who underwent coronary angiography in Tangshan Gongren Hospital from Feb 2016 to Feb 2017 were studied.Collected general information and other clinical indicators.Results Single factor analysis showed that the youth and middle age group among gender,smoking,drinking,BMI and family history of hereditary disease were greater than the elderly group（P〈0.05）,but hypertension,systolic blood pressure,diabetes,cholesterol,serum Lp-PLA2 level and Gensini score were lower than the elderly group（P〈0.05）.Logistic regression analysis showed that young and middle-aged degree aggravating the independent risk factors of coronary heart disease（CHD）of coronary lesions were diabetic,hypertension,smoking,high blood fat,family history and TC,（The OR value of 19.015、16.990、13.971、6.507、6.358、3.500）,HDL-C was protective,（OR=0.008）;The independent risk factors of coronary artery disease in elderly patients were the family history,drinking,TC,Lp-PLA2（The OR value of 5.421、2.613、1.445、1.009）.Conclusion The risk factors of coronary heart disease in different ages are different.Young and middle-aged patients with CHD are also related to diabetes,hypertension,smoking,family history and low HDL-C.Elderly patients with CHD are associated with alcohol and Lp-PLA2.Family history and hyperlipidemia can affect coronary artery disease.These risk factors can increase the degree of coronary atherosclerosis.

关 键 词：年龄 冠心病 危险因素 

分 类 号：R543[医药卫生—心血管疾病]