8-iso-PGF2α在COPD患者诱导痰和血清中的表达及意义  

Expression and significance of 8-iso-PGF2α in induced sputum and serum in patients with COPD

作　　者：王慧[1] 冯黎 郑玉琼[1] Wang Hui;Feng Li;Zheng Yuqiong(Department of Respiration, Chengdu First People＇s Hospital, Chengdu, Sichuan, 610051, China;Department of Radiology, Chengdu First People＇s Hospital, Chengdu, Sichuan, 610051, China)

机构地区：[1]成都市第一人民医院呼吸科,成都610051 [2]成都市第一人民医院放射科,成都610051

出　　处：《西南国防医药》2018年第5期414-417,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨8-异前列腺素F2α(8-iso-PGF2α)在慢性阻塞性肺疾病(COPD)患者诱导痰和血清中的表达及临床意义。方法选择COPD稳定期患者(SCOPD组)、COPD急性加重期患者(AECOPD组)及正常健康者(正常对照组)为研究对象,各30例,检测其诱导痰和血清8-iso-PGF2α水平,分析8-iso-PGF2α水平与第一秒用力呼吸容积(FEV1%)和BODE指数的相关性。结果正常对照组、SCOPD组和AECOPD组的诱导痰及血清8-iso-PGF2α水平依次增高,组间差异有统计学意义(P<0.05);SCOPD组诱导痰和血清8-iso-PGF2α水平与BODE评分均呈正相关,与FEV1%均呈负相关,而在AECOPD组中未观察到此相关性。结论 8-iso-PGF2α可能参与了COPD气道及全身的炎症反应,可能是COPD急性发作和疾病严重程度相关的新的生物学指标。Objective To explore the expression and clinical significance of 8-Iso-prostaglandin F2α （8-iso-PGF2α） in the induced sputum and serum in the hhhpatients with chronic obstructive pulmonanary disease （COPD）. Methods The patients with COPD in stable period （＂SCOPD group＂）, the patients with COPD in acute exacerbation period （AECOPD group） and healthy subjects （＂control group＂） （n=30, respectively） were selected to detect the levels of 8-iso-PGF2α in the induced sputum and serum and analyze the correlation between the levels of 8-iso-PGF2α and FEV1% and BODE index. Results The levels of 8-iso-PGF2α in the induced sputum and serum in the control group, SCOPD group and AECOPD group increased successively, and there were significant differences among the three groups （P 〈 0.05）; the levels of 8-iso-PGF2α in the induced sputum and sermn in the SCOPD group were positively correlated to the BODE scores and negatively correlated to FEV1%, but there was no such correlation in the AECOPD group. Conclusion 8-iso-PGF2α may be involved in the airway and systemic inflammatory reactions in COPD and may be a new biological index of acute outbreak of COPD and the severity of disease.

关 键 词：慢性阻塞性肺疾病 8-异前列腺素F2Α BODE指数 诱导痰 血清 

分 类 号：R563.8[医药卫生—呼吸系统]