苦参注射液联合GC化疗方案对晚期膀胱癌患者化疗耐受性及中位生存期的影响  

Effects of Matrine Injection Combined with GC Chemotherapy on Chemo Tolerance and Median Survival Time in Patients with Advanced Bladder Cancer

作　　者：刘涛[1] LIU Tao(Second People＇s Hospital, Jiaozuo Henan 454000, Chin)

机构地区：[1]河南省焦作市第二人民医院,河南焦作454000

出　　处：《药品评价》2018年第9期35-38,共4页Drug Evaluation

摘　　要：目的:观察苦参注射液联合吉西他滨+顺铂(GC)化疗方案对晚期膀胱癌患者化疗耐受性及中位生存期的影响。方法:选取2014年2月~2015年10月河南省焦作市第二人民医院74例晚期膀胱癌患者,采用随机数表法分组,各37例。对照组予以G C化疗方案治疗,观察组在对照组基础上予以苦参注射液治疗。对比两组治疗效果、化疗耐受性、生活质量、中位生存期。结果:与对照组治疗总有效率35.14%(13/37)相比,观察组59.46%(22/37)较高,差异有统计学意义(P<0.05);观察组不良反应发生率21.62%(8/37)较对照组43.24%(16/37)低,差异有统计学意义(P<0.05);治疗后两组EORTC QLQ-C30评分较治疗前高,观察组EORTC QLQ-C30评分较对照组高,差异有统计学意义(P<0.05);观察组中位生存期(19.2个月)较对照组(14.3个月)长,差异有统计学意义(P<0.05)。结论:苦参注射液联合GC化疗方案治疗晚期膀胱癌患者,疗效显著,可改善其生活质量,延长中位生存期,并能减少不良反应,有助于提高患者对化疗的耐受性。Objective： To investigate the effect of matrine injection combined with Gemcitabine ＋ Cisplatin（GC） chemotherapy on chemo tolerance and median survival time in patients with advanced bladder cancer. Methods： 74 cases of advanced bladder cancer patients in our hospital from February 2014 to October 2015 were randomly grouped with 37 cases in each. The control group was treated with GC chemotherapy, and the observation group was treated with matrine injection on the basis of the control group. The therapeutic effects, chemo tolerance, quality of life, and median survival time were compared between the two groups. Results： In comparison of the total effective rate with the control group 35.14%（13/37）, the observation group 59.46%（22/37） was higher, and the difference was statistically significant（P〈0.05）. The incidence of adverse reactions in the observation group 21.62%（8/37） was lower than that in the control group 43.24%（16/37）, and the difference was statistically significant（P〈0.05）. After treatment, the score of EORTC QLQ-C30 of the two groups was higher than that before the treatment, and the EORTC QLQ-C30 score of the observation group was higher than that of the control group（P〈0.05）. The median survival time of the observation group（19.2 months） was longer than that of the control group（14.3 months）, and the difference was statistically significant（P〈0.05）. Conclusion： Matrine injection combined with GC chemotherapy in the treatment of patients with advanced bladder cancer has significant curative effect. It can improve the quality of life, prolong the median survival time, and reduce the adverse reactions. Besides, it can help to improve the patient＇s tolerance to chemotherapy.

关 键 词：膀胱癌 苦参注射液 吉西他滨 顺铂 

分 类 号：R287[医药卫生—中药学]