儿童手足口病合并呼吸道感染住院时间与血常规的关系  

Effect of hospital stay on blood routine of hospitalized children with hand-foot-mouth disease complicated with respiratory tract infection

作　　者：任静朝[1] 段广才[2] 周广远[1] 秦露伟 杨道坤[3] 申宝深 张光文[3] REN Jing - chao;DUAN Guang - cai;ZHOU Guang - yuan;QIN Lu - wei;YANG Dao - kun;SHEN Bao - shen;ZHANG Guang - wen.(School of Public Health, Henan Collaborative Innovation Center of Mo- lecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, Chin)

机构地区：[1]新乡医学院公共卫生学院河南省分子诊断与医学检验技术协同创新中心,河南新乡453003 [2]郑州大学公共卫生学院,河南郑州450001 [3]新乡医学院第一附属医院感染科,河南新乡453100

出　　处：《广东医学》2018年第7期1022-1026,共5页Guangdong Medical Journal

基　　金：国家自然科学基金资助项目(编号:81573205);河南省高等学校重点科研项目(编号:15A330003);河南省博士后科研资助项目(编号:2015013);河南省分子诊断与医学检验技术协同创新中心开放课题资助项目(编号:XTCX-2015-PY5)

摘　　要：目的研究儿童手足口病合并呼吸道感染住院时间与血常规的关系,探索血常规辅助判断该病患儿是否适宜出院的价值。方法选取2015年5—11月收治,并在入院和出院进行两次血常规检测的手足口病合并呼吸道感染住院患儿224例作为研究对象,按照常见住院时间将对象分为4组(<6 d组、6 d组、7d组、>7 d组),利用方差分析或秩和检验分析经不同常规治疗时间血常规变化是否存在差异;不同治疗时间组血常规指标转正常率的比较利用x^2检验或精确概率法;利用配对x^2检验分析血常规指标在常规治疗前后异常情况是否存在差异。结果不同住院时间组的白细胞、中性粒细胞、淋巴细胞等血常规指标变化值差异无统计学意义(P>0.05)。不同住院时间组单核细胞转正常率差异有统计学意义(x^2=9.273 5,P=0.0259),而其他血常规指标转正常率在不同住院时间组间差异无统计学意义(P>0.05)。白细胞计数、中性细胞比例、淋巴细胞比例、淋巴细胞数、单核细胞数等指标的异常情况在不同住院时间组的治疗前后均差异有统计学意义(P<0.05)。结论目前医院常采用的不同常规治疗时间对手足口病合并呼吸道感染住院患儿血常规的影响并不大,血常规辅助判断该病患儿是否适宜出院的价值不大,住院时间不应主要依靠血常规检测。Objective To investiviate the effect of hospital stay on blood routine of hospitalized children with hand - foot - mouth disease complicated with respiratory tract infection and explore the value of blood routine test to judge whether the hospitalized children is suitable for discharge. Methods The subjects were children with hand - foot - mouth disease complicated with respiratory tract infection who were hospitalized between May 2015 and October 2016 and tested for blood routine at both admission and discharge. The subjects were divided into four groups according to the hospi- tal stay（ 〈6 days, 6 days, 7 days, 〉7 days ）. The difference in changes of blood routine among different hospital stay groups were analyzed by variance analysis or rank sum test. The rates of blood routine indices becoming normal were com- pared by chi square test or Fisher s exact test. The abnormality of blood routine indices was compared before and after treatment by paired chi square test. Results There was no significant difference in the changes of blood routine indices （ WBC, neutrophils, lymphocytes） before and after treatment among the different treatment time groups（ P 〉 0. 05 ）. There were significant differences in the turning normal rate of mononuclear cells among the different hospital stay groups （ Z2 = 9. 273 5, P = 0. 025 9 ）, and there was no significant difference in other blood routine indices （ P 〉 0. 05 ）. In different hospital stay groups, there were significant differences before and after treatment in the abnormalities of white blood cell count, neutrophil percentage, lymphocyte ratio, lymphocyte count, monocyte count （ P 〈 0. 05 ）. Conclusion The effects of different treatment times used in hospitals currently on blood routine of hospitalized children with respiratory tract infection complicated with hand - foot - mouth disease were little. There is little value of blood routine test to judge wheth-er the hospitalized child is suitable for discharge, and the hospitalization time

关 键 词：呼吸道感染 手足口病 住院时间 血常规 

分 类 号：R725[医药卫生—儿科]