2001-2015年我国医疗机构手术前和受血前临床患者梅毒阳性率的Meta分析  

Syphilis prevalence among clinical surgery patients and pre-transfusion patients during 2001 to 2015 in China:a meta-analysis

作　　者：李佳明 于欢[1] 毛翔[1] 虞炎秋[1] 耿文清[1] 姜拥军[1] 徐俊杰[1] LI Jiaming;YU Huan;MAO Xiang;YU Yanqiu;GENG Wenqing;JIANG Yongjun;XU Junjie.(Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, NO 1 Hospital of China Medical University, Shenyang 110001 , China)

机构地区：[1]中国医科大学附属第一医院检验科国家卫计委艾滋病免疫学重点实验室

出　　处：《中国艾滋病性病》2018年第4期377-382,共6页Chinese Journal of Aids & STD

基　　金：国家“十二五”科技重大专项基金资助项目(2012ZX10001-006);辽宁省教育厅重点实验室项目(LZ2014038);中国医科大学附属第一医院科技基金项目(FSFH1512)~~

摘　　要：目的分析我国医疗机构手术前和输血前患者的梅毒阳性检出率及其变化,为加强梅毒筛查工作提供理论依据。方法查找检索并提取2001-2015年中国临床术前/输血前人群梅毒调查文献,对提取的数据建立数据库后进行Meta分析。结果共纳入81篇合格文献,2001-2015年中国医疗机构手术前和受血前临床患者梅毒筛查阳性率为1.1%[95%可信区间（CI）：1.0%~1.3%],其中我国东北地区、西北地区,以及西南地区的梅毒筛查阳性率分别为2.7%（95%CI：0.8%~4.7%）、2.0%（95%CI：1.1%~2.9%）和1.9%（95%CI：1.3%~2.6%）,而华北地区仅为0.7%（95%CI：0.4%~0.9%）;2001-2005年梅毒阳性检出率为0.9%（95%CI：0.7%~1.1%）,而2011-2015年上升至1.2%（95%CI：0.8%~1.6%）。结论中国临床术前/输血前患者的梅毒检出率水平较高,且随时间呈上升趋势。相关部门需加强对梅毒的疫情监测和防控,应加强对术前/受血前临床患者中筛查出的梅毒感染者的转介和艾滋病病毒筛查工作,以掌握梅毒疫情和控制该人群梅毒的流行和扩散。Objective To describe and analyze the situation and the changing trend of syphilis prevalence among clinical surgery patients and pre-transfusion patients in recent years in China,to provide theoretical basis for the syphilis screening.Methods Literatures were retrieved to get the data of syphilis prevalence among clinical surgery patients and pre-transfusion patients and analyzed during the period of 2001 to 2015.Results Eighty-one literatures were selected.Between 2001 and 2015,pooled infection rates of syphilis among clinical surgery patients of China was 1.1% [95% confidence interval（CI）：1.0-1.3%].The distribution of syphilis prevalence differed greatly in different areas,with the prevalence of syphilis in the northeast,northwest,and southwest China were 2.7%（95%CI：0.8%-4.7%）,2.0%（95%CI：1.1%-2.9%）and 1.9%（95%CI：1.3%-2.6%）,respectively,but 0.7%（95%CI：0.4%-0.9%）in the north China.There was a significant increase of syphilis prevalence during the study period,which increased from 0.9%（95%CI：0.7%-1.1%）in 2001-2005 to 1.2%（95%CI：0.8%-1.6%）in 2011-2015.Conclusion The prevalence of syphilis among the clinical surgery patients and pre-transfusion patients has reached a high level and still shows rapid increasing trend.Related health sectors should strengthen the syphilis epidemic surveillance and prevention.At the same time,the patients infected with syphilis should be referred to syphilis treatment and HIV screening,in order to curb the further spread of syphilis.

关 键 词：术前/受血前检测群体 梅毒 META分析 

分 类 号：R759[医药卫生—皮肤病学与性病学]