5-氨基酮戊酸光动力诊断在尖锐湿疣随访中的应用  

Effect of 5-aminolaevulinic acid-photodynamic diagnosis of genital condylomata acuminata in the follow-up

作　　者：张恒坡[1] 曹冰青[1] 尹光文[2] 郝伟丽[1] 张大雷[1] 李韵[1] ZHANG Hengpo;CAO Bingqing;YIN Guangwen;HAO Weili;ZHANG Dalei;LI Yun(Anyang District Hospital, Anyang 455000, China;The First Affiliated Hospital of Zhengzhou University)

机构地区：[1]安阳地区医院,河南安阳455000 [2]郑州大学第一附属医院,郑州450000

出　　处：《中国艾滋病性病》2018年第4期410-412,共3页Chinese Journal of Aids & STD

基　　金：河南省濮阳市科技攻关项目(140639)~~

摘　　要：目的探讨5-氨基酮戊酸光动力诊断（ALA-PDD）在尖锐湿疣随访中的临床应用。方法对40例无疣体尖锐湿疣患者先后分别给予醋酸白试验和ALA-PDD检查,即分为醋酸白组和ALA组,12周后放大镜肉眼观察40例患者复发情况,用Logistic回归分析进一步探讨诊断随访中尖锐湿疣的相关变量,用受试者工作特征曲线（ROC曲线）确定诊断效能。结果 ALA组有28例发砖红色荧光,醋酸白组有9例变白,两组比较差异有统计学意义（χ~2=19.80,P〈0.05）。12周后随访40例患者中有27例出现疣体。应用Logistic回归分析显示,ALA-PDD是诊断随访中尖锐湿疣的独立因素（P〈0.05）。并采用ROC曲线分析,ALA-PDD的诊断效能较高,ROC曲线下面积（AUC）为0.905,其敏感度为96.3%,特异度为84.6%。结论 ALA-PDD对尖锐湿疣亚临床潜伏感染有一定意义,在随访观察中值得临床推广。Objective To understand the clinical efficacy of ALA photodynamic diagnosis（PDD）of condylomata acuminata（CA）in the case follow-up.Methods All of 40 CA patients were divided into two groups with one group given acetowhitening test,and another applied with ALA-PDD.The diagnostic effects of the two groups were observed after 12 weeks.Results The positive rates of ALA-PDD group was higher than the acetowhitening test group significantly.The differences between the two groups were statistically significant（χ~2=19.80,P0.05）.After 12 weeks,there were 27 cases showing positive characteristics.Logistic regression analysis showed that ALAPDD was risk factors for CA（P0.05）.The ROC curve revealed that the diagnosis efficacy of ALA-PDD was high.The area under ROC curve（AUC）was 0.905,with the sensitivity and specificity of 96.3% and 84.6% respectively.Conclusion ALA-PDD is effective in diagnosis of CA,especially subclinical and latent infections.

关 键 词：5-氨基酮戊酸光动力诊断 尖锐湿疣 醋酸白试验 wood灯 亚临床感染 潜伏感染 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]