温肾益气颗粒治疗慢性阻塞性肺疾病稳定期的临床疗效分析  

Clinical Observation on Treatment of Chronic Obstructive Pulmonary Disease in Stable Stage with Warming Kidney and Supplementing Qi Granule

作　　者：邓浩然 官凯悦 蔡宛如 晏露宁 赵玉秀 DENG Haoran;GUAN Kaiyue;CAI Wanru;et al(The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou （310005）,China)

机构地区：[1]浙江中医药大学附属第二医院,杭州310005

出　　处：《浙江中医药大学学报》2018年第4期266-271,共6页Journal of Zhejiang Chinese Medical University

基　　金：浙江省科学技术厅公益技术研究社会发展项目(2013C33183)~~

摘　　要：[目的]观察温肾益气颗粒治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期的临床疗效。[方法]将入组的80例COPD稳定期C组及D组患者随机分为治疗组和对照组各40例,其中C组予噻托溴铵18μg吸入,1次/d;D组在C组基础上加布地奈德/福莫特罗干粉(320μg/4.5μg/吸,60吸)吸入,2次/d。对照组依据COPD全球倡议(Global initiative for chronic obstructive lung disease,GOLD)指南2013年版予上述西药治疗,疗程12个月;治疗组在对照组西药基础上加温肾益气颗粒口服,1包/次,2次/d,温肾益气颗粒疗程3个月,西药疗程同对照组。评定两组患者治疗前后中医证候评分、生活质量指标、肺功能指标、肺过度充气指标的变化。[结果](1)临床证候疗效:治疗组总有效率优于对照组(P<0.05)。(2)中医症候评分:两组积分较治疗前均减少(P<0.01),且治疗组疗效优于对照组(P<0.05)。(3)肺功能:两组治疗前后组内及组间比较,肺功能指标改变均无统计学意义(均P>0.05)。(4)肺过度充气指标:两组治疗后各指标均好转,差异有统计学意义(P<0.01),组间比较治疗组疗效好于对照组(P<0.05)。(5)急性加重次数:两组治疗后均能减少急性加重发作频率(P<0.01),治疗组疗效好于对照组(P<0.05)。(6)生活质量:两组患者治疗后各指标均改善(P<0.01),组间比较治疗组各指标改善均优于对照组(P<0.01或P<0.05)。[结论]在西药治疗的基础上,加以温肾益气颗粒治疗COPD稳定期C组和D组患者,能缓解患者的临床症状,改善生活质量及肺过度充气状态,减少急性加重。[Objective] To observe the clinical effect of Warming Kidney and Supplementing Qi granules in the treatment of chronic obstructive pulmonary disease in stable stage. [Methods] 80 patients with COPD stable phases group C and group D were randomly divided into 40 cases in the treatment group and the control group.Control group using the GOLD 2013 guidelines given western medicine corresponding： group C： tiotropium bromide（18 μg, 10 capsules/box）inhalation, once a day. Group D： tiotropium bromide inhalation, once a day; plus budesonide/formoterol powder（320 μg/4.5μg/suction, 60 suction） inhalation,two times a day.The course of western medicine was 12 months.The treatment group was treated with Warming Kidney Supplementing Qi Granules（once a package, 2 times per day, 3 months） on the basis of western medicine.The course of western medicine was the same as that of the control group. Evaluate the effect of these observations of patients with TCM syndrome score, quality of life index, pulmonary function index, pulmonary hyperinflation. [Results]（1）The curative effect of clinical syndromes： The total effective rate of the treatment group was better than that of the control group, with a statistical significance（ P〈0.05）.（2）TCM syndrome score： The two groups of quantitative scores were lower than before treatment（ P〈0.01）, and between the two groups, the treatment group had better curative effect, and the symptom improvement was more obvious（P 〈0.05）.（3） Improvement of lung function： there were no significant differences in lung function between the two groups before and after treatment（P〉0.05）.（4）Pulmonary hyperinflation： compared with the baseline group,each index was improved after treatment in the two groups, and the difference was statistically significant（ P〈0.01）, and the comparison between the two groups, the effect of the treatment group after treatment was more obvious（P〈0.05）.（5）The number of acute exacerbations： within the t

关 键 词：慢性阻塞性肺疾病 温肾益气颗粒 中医药疗法 临床疗效 肺功能 生活质量 肺过度充气 急性加重次数 

分 类 号：R273[医药卫生—中西医结合]