前额纤维性脱发7例的临床特征及文献回顾  

The Clinical Features of Frontal Fibrosing Alopecia: A Review of 7 Cases

作　　者：薛紫 唐旭华[1] 王芳[1] 叶艳婷[1] 杨建[1] 章星琪[1] XUE Zi;TANG Xuhua;WANG Fang;YE Yanting;YANG Jian;ZHANG Xingqi(Department of Dermatology and Venereology, the First Affiliated Hospital, Sun Yet-sun University, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院皮肤性病科,广东广州510080

出　　处：《中国皮肤性病学杂志》2018年第5期523-528,共6页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金(81573066)

摘　　要：目的探讨前额纤维性脱发患者的临床表现、皮肤镜下特征、病理特点及疗效。方法收集本院毛发专科门诊2014年12月1日-2016年10月1日前额纤维性脱发患者7例,回顾分析其流行病学资料、临床表现、皮肤镜表现、病理特点及治疗效果。结果 7例患者均为女性,发病年龄19~54岁。所有患者均有前额、颞部发际线后退表现,眉毛脱失似与绝经相关。皮肤镜下,所有患者均有毛囊口消失、毛周红斑的征象,3例具有毛周角化。5例病理均提示毛囊周围淋巴细胞浸润伴纤维增生,5例患者接受口服羟氯喹、甲泼尼龙,外用卤米松或0.1%他克莫司乳膏治疗,其发际线后退速度减慢或停止。结论前额纤维性脱发为前额和颞部发际线处的瘢痕性脱发,好发于绝经期女性,亦可侵及眉毛和腋毛,治疗不能导致毛囊的再生,但可减缓病情进展。Objective To describe the clinical and dermoscopic features, and the response to treatment in patients with frontal fibrosing alopecia （FFA） in China. Methods Data analysis from case notes, which included epidemiologieal information, clinical mani- festation, dermoscopic features, histopathology and response to treatment, was per- formed on seven patients with a diagnosis of FFA presenting to Outpatient Department of our hospital from December 2014 to October 2016. Results All patients in this cohort were females, with age at onset of between 19 and 54 years. All patients had recession of frontal and temporal hairline. All postmenopausal patients had complete or partial loss of eyebrows. Dermoscopic features included disapearance of follicular ostia and presence of perifollicular erythema in all patients, and perifollicular hyper- keratosis in 3. Biopsy of five patients revealed lymphocytic infiltration with perifollic- ular fibrosis. After treatment with oral hydroxyehloroquine, methylprednisolone, com- pound glycyrrhizin and topical halometasone cream or 0.1% tacrolimus cream, their frontal hairline recession were slowed down or stable as a response to the treatment.Conclusion FFA is a kind of cicatricial alopecia which typically affects postmenopa- usal women, with typical features of recession of frontal and temporal hairline, com- plete or partial loss of eyebrows or hircus. Corresponding treatment may contribute to slow recession of hairline other than regeneration of hair follicles.

关 键 词：前额纤维性脱发 临床表现 诊断 治疗 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]