巨噬细胞极化与微生物感染进程  

Macrophage Polarization and Microbial Infection Process

作　　者：张莲[1] 刘栋华[1] ZHANG Lian;LIU Donghua(Dpartment of Dermatology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China)

机构地区：[1]广西医科大学第一附属医院皮肤性病科,广西南宁530021

出　　处：《中国皮肤性病学杂志》2018年第5期592-595,共4页The Chinese Journal of Dermatovenereology

摘　　要：巨噬细胞在宿主抗病原体、内环境稳态、组织修复、防御有重要作用。巨噬细胞在不同条件刺激下,可极化为M1型和M2型巨噬细胞;M1型分泌多种趋化因子、炎症因子,发挥促炎能力、抗原提呈能力,增强机体防御能力,消灭病原微生物;M2型巨噬细胞通常发挥调节性效应抑制炎症反应和细胞免疫应答,从而减轻病理性损伤,促进伤口愈合、组织修复等作用。巨噬细胞的偏离活化或者过度活化,对有效抗感染免疫的发生产生显著影响,并介导免疫病理损伤。研究表明,病原体可通过改变巨噬细胞代谢来调节巨噬细胞极化。本文从病原体调节巨噬细胞代谢来改变微环境从而调控巨噬细胞极化情况进行综述。Macrophages play an important role in host anti-pathogen, homeostasis, tissue repair and defense. Under different conditions of stimulation, macrophages can be polarized to M1 and M2 macrophages. M1 macrophages secrete a variety of chemokines and in- flammatory cytokines, which have pro-inflammatory and antigen-presenting capacity, abilities of enhancing the body defense and eliminating pathogenic microorganisms. By contrast, M2 macrophages usually exert a regulatory effect on inhibition of inflam- matory response and cellular immune response, which reduces pathological damage and promotes wound healing and tissue repair. Deviations or overactivation of macro- phages generate a significant impact on effective development of anti-infectious immu- nity and mediated immune pathology damage. Numerous studies have shown that mac- rophage polarization can be regulated by altering macrophage metabolism. In this re- view, we summarize that macrophages polarization are regulated by the variation of microenvironment which can be changed with macrophages metabolism for the manip- ulation of pathogens.

关 键 词：巨噬细胞极化 代谢 进程 

分 类 号：R37[医药卫生—病原生物学]