可吸收医用膜预防和治疗中耳粘连的实验研究  

Experimental study on application of absorbable medical film to prevent and cure middle-ear adhesive

作　　者：柴先奇 黄若葵 何英[2] CHAI Xian-qi;HUANG Ruo-kui;HE Ying(Department of Otolaryngology, Yuebei People＇s Hospital Affiliated to Shantou University School of Medicine, Shaoguan 512000, China;Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou 510515, China)

机构地区：[1]汕头大学医学院附属粤北人民医院耳鼻咽喉科,广东韶关512000 [2]南方医科大学附属南方医院耳鼻咽喉头颈外科,广东广州510515

出　　处：《中国耳鼻咽喉颅底外科杂志》2018年第2期152-155,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的探讨可吸收医用膜(粘克)对耳科术后中耳粘连的预防作用。方法选取听阈正常、无耳科疾病的正常豚鼠36只,随机分为3组,均通过堵塞咽鼓管来诱发中耳黏膜炎性渗出改变,在豚鼠的中耳鼓岬部植入粘克阻隔材料(试验组1),并在另外两组的豚鼠中耳内植入硅胶片(试验组2)和不植入任何材料(对照组)作为对照,每组豚鼠分别在术后15 d和90 d各处死6只,以了解可吸收医用膜阻隔中耳粘连的作用。结果植入粘克材料的豚鼠听力阈值改变较小,与其他两组比较差异具有统计学意义(P<0.05)。对植入阻隔材料后豚鼠的听泡进行病理形态学观察显示:与其他两组形成大量纤维肉芽组织和大片坏死相比,粘克材料组形成的纤维肉芽组织较少,且形成局限性包裹,并有腔隙形成,有效的阻隔了粘连。结论粘克材料具有更好的生物相容性,是很好的阻隔中耳粘连的生物材料。Objective To explore the effect of absorbable medical film for the prevention of postoperative middle ear adhesion. Methods 36 guinea pigs with normal hearing threshold and without ear diseases were included in this study.The animals were randomly and equally divided into three groups. In order to induce otitis media,all guinea pigs underwent permanent clogging of the eustachian tube. Meanwhile,an absorbable medical film was implanted on the promontory surface of animals in the experiment group I and a silicon member in the experiment group II. The animals of the control group received only clogging without implantation. At the 15 th and 90 th day after the process,6 animals in each group were sacrificed to observe the preventive effect of implants on middle ear adhesion. Results The threshold change in the experiment group I was smaller than those in the experiment group II and the control group respectively,their differences were statistically significant（both P 〈 0.05）. Histopathological study of the tympanic bullae demonstrated less granulomatous and fibrous tissue,localized encapsulation with development of lacunae in the experiment group I,which indicated that the absorbable medical film had good preventive effect for postoperative middle ear adhesion. Conclusion With good biocompatibility,absorbable medical film is an excellent biological material to prevent middle ear adhesion.

关 键 词：可吸收医用膜 粘连 中耳炎 生物材料 豚鼠 

分 类 号：R764.2[医药卫生—耳鼻咽喉科]