自噬与氧化应激在心血管疾病中的研究进展  

The progress of autophagy and oxidative stress in cardiovascular diseases

作　　者：刘德敏[1] 贾宏宇[1] 柴文静[1] 呼海娟[1] 崔炜[1] LIU Demin;JIA Hongyu;CHAI Wenjing;HU Haijuan;CUI Wei(Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei,050000 ,Chin)

机构地区：[1]河北医科大学第二医院心内科

出　　处：《临床心血管病杂志》2018年第4期402-407,共6页Journal of Clinical Cardiology

摘　　要：自噬作为一种高度保守的自我保护机制在多种心血管疾病特别是动脉粥样硬化、心肌缺血再灌注损伤、心力衰竭中发挥重要作用,并与内质网和线粒体产生的活性氧簇(ROS)相互作用,全面了解二者间关系可能为预防和治疗心血管疾病提供新的策略。Autophagy,as a highly conserved mechanism of self-protection,plays an important role in many cardiovascular diseases,especially in atherosclerosis,myocardial ischemia reperfusion injury and heart failure.With the endoplasmic reticulum and mitochondria（ROS）interaction,a comprehensive understanding of the relationship between the two may provide a new strategy for the prevention and treatment of cardiovascular disease.

关 键 词：自噬 氧化应激 心血管疾病 

分 类 号：R34[医药卫生—基础医学]