微流纺海藻酸盐基纤维敷料的制备及其性能  

Preparation and characterization of microfluidic spinning alginate-based composite fibrous dressings

作　　者：张小林 黄晨[1] 靳向煜[1] ZHANG Xiaolin;HUANG Chen;JIN Xiangyu(College of Textiles, Donghua University, Shanghai 201620, China)

机构地区：[1]东华大学纺织学院,上海201620

出　　处：《纺织学报》2018年第5期1-7,共7页Journal of Textile Research

基　　金：中央高校基本科研业务费专项资金资助项目(CUSF-DH-D-2017009)

摘　　要：为制备一种可用于创面治疗的新型海藻酸盐基纤维敷料,以海藻酸、二氧化硅、羟基磷灰石为芯层流,氯化钙水溶液为皮层流,采用自制微流纺丝设备制备了海藻酸盐基复合纤维敷料,通过人体皮肤成纤维细胞和角质化细胞增殖及迁移实验研究了其生物毒性,对海藻酸盐纤维的降解性能、力学性能、体外的生物矿化进行了研究。结果表明:二氧化硅颗粒的加入使得海藻酸盐纤维敷料在降解过程中表面有矿物沉积,且表面呈现孔隙结构,有益于营养物质的运输及组织再生长;所制纤维敷料无细胞毒性;含有二氧化硅和羟基磷灰石颗粒的复合纤维比纯海藻酸盐纤维降解度降低20%左右,断裂应力提高约18%。To prepare alginate-based fibrous dressings for wound healing,the alginate-silica and alginate-hydroxyapatite composite fibrous dressings were prepared by blending nano-silica/hydroxyapatite with alginate as core flow and calcium chloride water solution as cortical flow by microfluidic spinning.The characterization of biotoxicity,in vitro biomineralization and degradation behavior,mechanical performances were carried out.Results demonstrate that the incorporation of silica particles in alginate fibers exhibite the mineral deposition in the process of degradagion and porosity struture appears on the surface benificial for nutrient transportation and tissue regeneration.The prompt proliferation of fibroblast and keratinocytes cells indicate no significant cytotoxicity of prepared dressings.Furthermore,the reinforced composite alginate fibrous dressings containing silica and hydroxyapatite particle decreases the degradation degree by about 20% and increases the breaking stress by about 18%,compared with the pure alginate fibers.

关 键 词：海藻酸盐 二氧化硅 羟基磷灰石 纤维敷料 微流纺 

分 类 号：TQ342.87[化学工程—化纤工业]