幽门螺杆菌现症感染与慢性荨麻疹的相关性研究  

Correlation between helicobacter pylori infection and chronic urticaria

作　　者：李嘉彦[1] 罗育武[1] 李平[1] 黄平[1] 梁碧华[1] Li Jiayan;Luo Yuwu;Li Ping;Huang Ping;Liang Bihua(Guangzhou Dermatologic Institute, Guangzhou 510095, China)

机构地区：[1]广州市皮肤病防治所,510000

出　　处：《国际医药卫生导报》2018年第10期1488-1489,1492,共3页International Medicine and Health Guidance News

基　　金：广州市医药卫生科技项目（20151A011065）

摘　　要：目的 探讨幽门螺杆菌（Helicobacter pylori,HP）现症感染与慢性荨麻疹的相关性,为临床慢性荨麻疹患者筛查幽门螺杆菌的现症感染和进行相关的治疗提供理论依据.方法 选取2016年1月至2017年9月在本所诊断为荨麻疹的518例患者,按荨麻疹的不同发病状态分为三组,其中A组慢性荨麻疹患者308例,B组慢性荨麻疹急性发作期患者70例,C组急性荨麻疹患者140例,并随机选取本院体检的正常人群150名作为对照组,检测血清幽门螺杆菌现症感染的特征性蛋白Cls.11,并按上述分组结果进行统计学分析.结果 A组HP现症感染阳性137例,占44.48％;B组HP现症感染阳性38例,阳性率为54.29％;C组HP现症感染阳性39例,占27.86％;正常对照组HP现症感染阳性43例,占30.71％.A组与B组以及C组与对照组的结果经卡方检验,差异无统计学意义（均P＞0.05）,A组和B组分别与C组和对照组的两两比较,差异均有统计学意义（均P＜ 0.05）.结论 该研究提示HP现症感染和慢性荨麻疹,特别是慢性荨麻疹急性发作患者相关,这为临床针对HP现症感染的慢性荨麻疹进行抗HP治疗提供了理论依据.Objective To investigate the relationship between Helicobacter pylori （HP） infection and chronic urticaria and provide a theoretical basis for the screening and treatment of HP infection in patients with chronic urticaria. Methods 518 patients diagnosed with urticaria at our hospital from January 2016 to September 2017 were divided into three groups according to the pathogenesis of urticaria. Among them, 308 patients with chronic urticaria were set as group A, 70 patients with chronic urticaria during acute attack period group B, and 140 patients with acute urticaria group C. 150 healthy subjects at our hospital were randomly selected as a control group. The characteristic protein Cls.11 of Helicobacter pylori infection was tested in these groups. A statistical analysis was carried out on the test results. Results 137 cases （44.48%） was positive in HP infection in group A, 38 cases （54.29%） in group B, 39 cases （27.86%） in group C, ans 43 cases （30.71%） in the control group; there were no statistical differences between group A and group B and between group C and control group （P〉 0.05） but were between group A and group C, between group A and the control group, between group B and group C, and between group B and the control group （all P〈 0.05）. Conclusion This study suggests that the current infection of HP associates with chronic urticaria, especially acute onset of chronic urticaria. This provides a theoretical basis for the clinical anti-HP treatment of chronic urticaria patients with current HP infection.

关 键 词：幽门螺杆菌 慢性荨麻疹 现症感染 急性发作 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]