阻塞性睡眠呼吸暂停低通气综合征醛醇脱氢酶基因多态性的临床研究  

A clinical study on ADH2 and ALDH2 gene polymorphism in obstructive sleep apnea syndrome patients

作　　者：高蔚[1] 嵇桂娟 张文辉 施斌[1] 翁婷[1] GAO Wei;JI Guijuan;ZHANG Wenhui;SHI Bin;WENG Ting(Department of Respiratory Medicine, Suqian People＇s Hospital, Nanjing Drum Tower Hospital Group, Suqian, Jiangsu 223800, China;Department of Respiratory Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002)

机构地区：[1]南京鼓楼医院集团宿迁市人民医院呼吸科,江苏宿迁223800 [2]徐州医科大学附属医院呼吸科,江苏徐州221002

出　　处：《徐州医科大学学报》2018年第4期249-253,共5页Journal of Xuzhou Medical University

基　　金：宿迁市科技支撑计划项目（S201518）

摘　　要：目的 探讨长期大量饮酒及乙醇脱氢酶2（ADH2）、乙醛脱氢酶2（ALDH2）基因多态性和阻塞性睡眠呼吸暂停低通气综合征的关系。方法 以321例打鼾男性为研究对象，行多导睡眠呼吸监测并分析数据后分为OSAHS组208例和非OSAHS对照组113例。应用专门的问卷，调查所有研究对象的饮酒史，计算平均饮酒量及累积饮酒量，将患者分为少量、中量、大量饮酒组，分析长期大量酒精摄入与OSAHS的相关关系；采用聚合酶链式反应-连接酶检测反应（PCR-LDR）技术，检测乙醇脱氢酶ADH2 Arg47His和乙醛脱氢酶ALDH2 Glu487Lys基因型，探讨这两种基因型多态性与OSAHS的相关关系。结果 OSAHS组饮酒率为42.80％，非OSAHS组为38.41％，两组比较差异无统计学意义（P〉0.05）；入组对象中少量饮酒者52例，中量31例，大量89例；大量饮酒者患OSAHS的条件OR值为2.310（95％CI：1.364-1.967，P=0.013）； OSAHS组大量饮酒者较中量及小量者有更低夜间血氧饱和度及更高AHI；与携带ADH2（A/A）或ALDH2（G/G）基因型者相比，其它基因型发生OSAHS的危险性未增加（P〉0.05）。结论 长期大量饮酒增加OSAHS及重度OSAHS患病率，ADH2、ALDH2基因多态性与OSAHS易感性无关。Objective To investigate the relationship among long - term alcohol drinking and dehydrogenase 2 （ADH2）, aldehyde dehydrogenase 2 （ALDH2） gene polymorphism, and obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods A total of 321 patients with snoring were studied. After overnight sleep monitoring, they were divided into an OSAHS group （ n = 208 ） and a non - OSAHS group （ n = 113 ）. The drinking history of all patients was investigated, and the mean monthly alcohol consumption and total alcohol consumption were calculated. The relationship between long - term of alcohol intake and OSAHS were analyzed. The polymorphisms of ADH2 Arg47His and ALDH2 Gln487Lys were detected and their relationship with OSAHS was discussed. Results The alcohol consumption rate was 42.80% in the OSAHS group and 38.41% in the non- OSAHS group, without statistical difference （P 〉 0.05）. Long -term of heavy alcohol consumption may be a risk factor of OSAHS （r = 2. 310, P = 0. 013 ）. Heavy alcohol drinkers showed lower oxygen saturation at night and higher apnea- hypopnea index （AHI）. Compared with ADH2 AA and AL- DH2 GG genotype carriers, patients with other genotypes did not showed an increased risk of OSAHS （P 〉 0.05 ）. Conclusions Long - term of heavy alcohol consumption may increase the incidence of OSAHS. Genetic polymorphisms of ADH2 and ALDH2 are not related to the susceptibility of OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 饮酒 乙醇脱氢酶2 乙醛脱氢酶2 基因多态性 

分 类 号：R766.04[医药卫生—耳鼻咽喉科]