骨小梁Micro-CT图像形态计量学参数计算方法综述  

A Methodological Review on Morphometric Parameters of Micro-CT Trabecular Bone Images

作　　者：刘蓉 郭新路 张亚坤 王永轩[3] Liu Rong;Guo Xinlu;Zhang Yakun;Wang Yongxuan(Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China;Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning, China)

机构地区：[1]大连理工大学电子信息与电气工程学部生物医学工程系,辽宁大连116024 [2]中国生物医学工程学会 [3]大连大学附属中山医院,辽宁大连116001

出　　处：《中国生物医学工程学报》2018年第2期237-246,共10页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(61573079); 大连大学博士启动项目(20151QL06); 中央高校基本科研业务费专项资金(DUT15QY58)

摘　　要：骨质疏松症是骨科领域的研究热点之一,研究发现,除骨密度(骨量)改变的因素外,骨小梁的结构变化也是患病的重要影响因素。骨小梁形态计量学分析是研究骨小梁结构形态变化的一种重要方法。基于骨小梁的Micro-CT图像介绍部分骨小梁形态学参数的计算方法,主要包括骨小梁各向异性、连通性、结构模型指数以及纹理等不同特征,同时列举部分相关研究实例,总结上述形态学参数的适用性以及优缺点,为更加有效地评价骨质疏松状态以及药物治疗效果提供依据。Osteoporosis is one of the hotspots in the orthopedic field. Some studies have revealed that not only the changes in bone mineral density（ bone mass） but also changes of trabecular bone structure are pathogenic factors. The trabecular bone morphometric analysis is one kinds of important method to study trabecular bone structure change. In this paper,some methods to calculate the trabecular bone morphometric parameters based on Micro-CT images were introduced,such as trabecular anisotropy,connectivity,structure model index,texture and other trabecular bone characteristics. Meanwhile,some examples were given to summarize the applicability,pros and cons of the trabecular bone morphometric parameters to provide evidence for the effective evaluation of osteoporosis and drug treatment.

关 键 词：骨质疏松症 骨小梁 形态计量学 图像分析 

分 类 号：R318[医药卫生—生物医学工程]