重组人脑利钠肽联合多巴胺对心肾综合征伴低血压的疗效及对血清NT-proBNP水平的影响  

Curative Efficacy of Recombinant Human Brain Natriuretic Peptide Combined with Dopamine in Treatment of Cardio Renal Syndrome with Hypotension and Its Effects on Serum NT-proBNP Level

作　　者：文宇[1] 吴屹[1] 林芳 唐伟 何森[2] WEN Yu 1, WU Yi 1, LIN Fang 1, TANG Wei 1, HE Sen2(1 Department of geriatric comprehensive surgery, Mianyang Central Hospital, Mianyang, Sichuan, 621000, China; 2 Department of Cardiology, West China Hospital, Sichuan Universi（y, Chengdu, Sichuan, 610000, China)

机构地区：[1]绵阳市中心医院老年综合科,四川绵阳621000 [2]四川大学华西医院心内科,四川成都610000

出　　处：《现代生物医学进展》2018年第6期1137-1140,共4页Progress in Modern Biomedicine

基　　金：四川省自然科学基金项目(12H1483)

摘　　要：目的:研究重组人脑利钠肽联合多巴胺对心肾综合征伴低血压的疗效及对血清NT-proBNP水平的影响。方法:收集2015年4月至2016年4月我院的90例心肾综合征伴低血压患者,按抽签法分为实验组和对照组,每组45例。对照组用多巴胺治疗,实验组在对照组基础上加用重组人脑利钠肽。观察两组治疗疗效,治疗前后血压、心率、心动图指标每搏输出量(SV)、左心室射血分数(LVEF)、左心室舒张末内径(LVEDD),N末端前体脑钠肽(NT-proBNP)、血肌酐(SCr)、胱抑素C(Cys C)水平的变化。结果:治疗后,实验组总有效率为93.33%,显著高于对照组(68.88%,P<0.05);SBP、DBP、MAP、SV、LVEF均显著高于对照组(P<0.05),HR、血清NT-proBNP、SCr水平显著低于对照组(P<0.05);两组LVEDD比较差异无统计学意义(P>0.05)。结论:重组人脑利钠肽联合多巴胺对心肾综合征伴低血压的疗效显著,可缓解心脏负荷,改善心肾功能,降低NT-proBNP水平,提高治疗安全性。Objective： To study the curative efficacy of recombinant human brain natriuretic peptide combined with dopamine in the treatment of cardio renal syndrome with hypotension and its effects on the serum NT-proBNP level. Methods： 90 patients of cardio renal syndrome with hypotension who were treated from April 2015 to April 2016 in our hospital were selected as research objects. According to draw method, they were divided into the control group and the experimental group with 45 cases in each group. The control group was treated with dopamine, while the observation group was treated with recombinant human brain natriuretic peptide based on the control group. Then the therapeutic efficacy, changes of blood pressure, heart rate changes, cardiac indexes, stroke volume （SV）, Left ventricular eject fraction （LVEF）, Left ventricular end-diastolic diameter （LVEDD）, serum N-terminal brain natriuretic peptide （NT-proBNP）, creatinine （SCr） and Cystatin C （Cys C） levels before and after treatment were measured between two groups. Results： After treatment, the total effective rate of experimental group was 93.33%, which was significantly higher than that of the control group （68.88%, P 〈0.05）; the SBP, DBP, MAP, SV, LVEF were significantly higher than those of the control group （P 〈0.05）, HR, serum NT-proBNP, SCr levels were significantly lower than the control group （P 〈0.05）, there was no difference in LVEDD between the two groups （P 〉0.05）. Conclusion： Recombinant human brain natriuretic peptide combined with dopamine is effective for cardio renal syndrome with hypotension, which can relieve the cardiac load, improve the function of heart and kidney, decrease the level of NT-proBNP and increase the safety.

关 键 词：重组人脑利钠肽 多巴胺 心肾综合征 低血压 N末端前体脑钠肽 

分 类 号：R541.61[医药卫生—心血管疾病] R692[医药卫生—内科学]