异染色质相关蛋白1在哺乳动物生殖中作用的研究进展  

Research Progress of the Role of Heterochromatin Associated Protein 1 in the Mammal Reproduction

作　　者：廖晖淇 张昌军[1] 刁红录[1] LIAO Hui-qi, ZHANG Chang-jun, DIAO Hong-lu(Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, Chin)

机构地区：[1]湖北医药学院人民医院生殖医学中心,湖北十堰442000

出　　处：《现代生物医学进展》2018年第6期1197-1200,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(2015CFB543);湖北医药学院中青年创新团队(2014CXX03);湖北医药学院重点学科建设资助项目

摘　　要：异染色质是指在细胞周期中维持凝缩状态的染色质,具有维持染色体稳定性和调节真核细胞基因表达的作用。异染色质相关蛋白1(heterochromatin associated protein1,HP1)是异染色质的特征性蛋白,进化高度保守,在哺乳动物有三种亚型:HP1α、HP1β和HP1γ(分别由CBX5、CBX1和CBX3基因编码),在哺乳动物配子发生、受精、胚胎的着床及胚胎发育过程中都有着自己独特的作用,本文主要对HP1的各个亚型在哺乳动物生殖过程中的作用及其异常对生殖过程的影响作一综述。Heterochromatin is the chromatin that maintains condensed in the cell cycle, which can maintain the chromosome stability and regulate the expression of eukaryotic gene. Heterochromatin associated protein 1 （HP1） is characteristic of heterochromatin protein, whose evolution is highly conserved. There are three subtypes： HP1α, HP1β and HP1γ in mammals （three proteins are encoded as CBX5, CBXland CBX3 respectively）. HPls has unique role in the gametogenesis, fertilization, embryonic development and embryo implantation. In this paper, we review the role of three subtypes during mammal reproductive process.

关 键 词：异染色质相关蛋白1 异染色质 哺乳动物 生殖 

分 类 号：Q132.7[生物学—普通生物学] Q492