AT1R基因A1166C多态性与山东地区汉族人群原发性高血压的相关性研究  

Association between A1166C polymorphism of AT1R gene and essential hypertension in Shandong Hans

作　　者：刘稳柱 Liu Wengzhu(Heze Medical College, Heze 274000, Shandon)

机构地区：[1]菏泽医学专科学校,山东菏泽274000

出　　处：《菏泽医学专科学校学报》2018年第1期1-3,13,共4页Journal of Heze Medical College

摘　　要：目的研究血管紧张素1型受体基因A1166C多态性与山东省地区汉族原发性高血压的相关性。方法确诊原发性高血压300例为实验组;健康成年人200例为对照组。采用荧光定量PCR技术检测外周血全基因组DNA中AT1R基因A1166C的多态性。应用SPSS软件,所获数据采用方差分析、t检验和2检验。结果实验组的AA、AC和CC基因型频率分别为83.7%、16.3%和0,对照组中分别为95.0%、5.0%和0,两组比较P<0.005;实验组中A与C等位基因频率分别为91.8%、8.2%,对照组中分别为97.5%、2.5%,两组比较P<0.005。两组BMI、收缩压、舒张压、年龄比较,P均<0.0005;两组TC、TG比较,P均>0.05;两组年龄比较,P<0.001。两组AA、AC、CC及A、C比较,P均<0.005。结论血管紧张素1型受体基因A1166C多态性与汉族原发性高血压患者的发病存在一定的相关性,AC基因型和C等位基因可能是原发性高血压的潜在危险因素。Objective To study the relationship between A1166C polymorphism and essential hypertension in Shandong Hans. Methods 300 patients with essential hypertension were in the experimental group. 200 healthy adults were in the control group. The Al166C polymorphism of ATIR gene in genomic DNA of peripheral blood was detected by fluorescence quantitative PCR. Using SPSS software, the data obtained was analyzed by variance analysis, t test and χ^2test. Results The frequencies of AA, AC and CC genotypes in the experimental group were 83.7%, 16.3% and 0 respectively and those were 95.0%, 5.0% and 0 respectively in the control group. The comparison of them was P〈0.005. The allele frequencies of A and C were 91.8% and 8.2% in the experimental group and those were 97.5 % and 2.5 % in the control group respectively. The comparison of them was P〈0.005. BMI, systolic blood pressure, diastolic blood pressure and age were compared between the two groups with P〈0.0005. Comparison of TC and TG between the two groups was with P〉0.05. The ages of the two groups was compared with P〈0.001. AA, AC, CC and A, C were compared between the two groups with P〈 0.005. Conclusion The A1166C polymorphism is related to the onset of essential hypertension in Shandong Hans. AC genotype and C allele maybe the potential risk factors of essential hypertension.

关 键 词：A1166C基因 多态性 原发性高血压 

分 类 号：R34[医药卫生—基础医学] R544.1