血清降钙素原动态检出值的变化对早期诊断恙虫病患者的临床意义及其防治对策  

Clinical Significance of Detected Dynamic Procalcitonin in Early Diagnosed Patient with Scrub-typhus and Its Strategies

作　　者：蔡杰[1] 李琼[1] 曹堃[1] 郑亮[1] 李祖栋 梁小维[1] CAI Jie;LI Qiong;CAO Kun;ZHENG Liang;LI Zhu-dong;LIANG Xiao-wei(Zhanjiang Cental People＇s Hospital. Zhanjiang Guangdong 524045, China;Xinyi Hospital of Traditional Chinese Medicine, Xinvi Guangdong 525300. China)

机构地区：[1]湛江中心人民医院,广东湛江524045 [2]信宜市中医院,广东信宜525300

出　　处：《抗感染药学》2018年第3期463-465,共3页Anti-infection Pharmacy

摘　　要：目的:探讨血清降钙素原(PCT)动态检出值的变化对早期诊断恙虫病患者的临床意义及其防治对策。方法:选取2014年1月—2016年12月间收治的住院治疗诊断为恙虫病的58例患者资料(治疗组);另选取同期住院治疗诊断为恙虫病的非感染性发热患者30例资料(对照组);分析两组资料中患者的年龄、性别,以及WBC、ESR、hs CRP和PCT水平测得值的变化情况。结果:治疗组恙虫病患者治疗前PCT阳性率为93.10%高于外斐氏试验OXK抗体、白细胞(WBC)、血沉(ESR)、超敏C反应蛋白(hs CRP)检出结果的阳性率(P<0.05);WBC、ESR、CRP水平测得值与对照组比较其差异无统计学意义(P>0.05),但PCT水平测得值与对照组比较其差异有统计学意义(P<0.05),且经受试者工作特征曲线(ROC)分析,当临界值取0.51时其灵敏度和特异度分别为93.10%和91.80%;治疗组患者治疗后PCT水平测得值与治疗前比较其差异有统计学意义(P<0.05)。结论:采用PCT检出早期诊断恙虫病患者具有较高的诊断价值,并可通过监测患者PCT水平的变化,评估恙虫病患者的治疗效果。Objective： To explore the clinical significance of detected dynamic procalcitonin（PCT） in early diag- nosed patients with Scrub-typhus and its strategies. Methods： The data of 58 cases of the patients were diagnosed as scrub-typhus from January 2014 to December 2016 in hospital who were selected as experimental group： and the data of 30 cases of non-infectious fever in patients were selected as control group. The data of white blood cclI（WBC）, eryth- rocyte sedimentation rate （ESR）, hypersensitive c-reactive protein（hs-CRP） and PCT in different groups were compared and analyzed. Results： The positive rate of PCT （93.10%） was higher than that of OXK antibody, WBC, ESR and hs- CRP before treatment in experiment group（P〈 0.05 ）. Compared with control group, measured value of WBC, ESR and CRP were shown to have no significant difference （P〉0.05）, while PCT level was shown to have statistical signifi- cance （P〈 0.05 ）. Receiver operating characteristic （ROC） curve analysis showed that the sensitivity was 93.1% and the specificity was 91.8%, when threshold was 0.51.1n experimental group, there were significant differences in PCT after and before the treatment（P〈 0.05）. Conclusion： PCT value was used to detecte in early diagnosed patients with Scrub- typhus which has high diagnostic significance. Dynamic monitoring the PCT level can be used to evaluate the therapeu- tic effect of patients with scrub typhus. The clinical efficacy of Scrtthophus patients can be evaluated by monitoring the changes of PCT level in patients.

关 键 词：恙虫病 白细胞 血沉 超敏C反应蛋白 血清降钙素原 

分 类 号：R969.3[医药卫生—药理学]