自身免疫性疾病子痫前期的防范  

Prevention of preeclampsia in autoimmune disease

作　　者：宋亦军[1] 刘俊涛[1] SONG Yi-jun;LIU Jun-tao.(Department of Obstetrics and Gynecology, Peking Union Medical Col- lege Hospital, Peking Union Medical College, Chi- nese Academy of Medical Science, Beijing 100730, China)

机构地区：[1]中国医学科学院北京协和医院妇产科,北京100730

出　　处：《中国实用妇科与产科杂志》2018年第5期475-479,共5页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：子痫前期是常见的妊娠期并发症,孕产妇及围产儿患病率和病死率较高,以妊娠20周后出现高血压和蛋白尿为主要临床表现。在子痫前期出现临床症状之前对子痫前期高危人群进行预测较为困难。系统性红斑狼疮(SLE)和抗磷脂综合征(APS)患者妊娠期子痫前期发生的风险更高。对SLE和APS患者在妊娠期间子痫前期发病机制的理解有助于解释这些自身免疫性疾病患者为什么子痫前期发生率增加。对高危SLE和APS患者的子痫前期进行早期预测和识别,对这些高危患者进行密切监测和治疗,是改善不良母儿结局的关键。对高危SLE和APS患者使用小剂量阿司匹林预防治疗是迄今为止最好的子痫前期的预防方法。Preeclampsia is a common complication of pregnancy with high maternal and perinatal morbidity and mortality,whose main clinical manifestataions are hypertension and proteinuria after 20 weeks of gestation.It is difficult to identify pregnant women at high risk of preeclampsia before it presents clinically.Both systemic lupus erythematosus（SLE）and antiphospholipid syndrome（APS）put pregnancies at even high risk of preeclampsia.Understanding of the mechanisms through which SLE and APS contribute to preeclampsia helps to explain the high incidence rate of preeclampsia.To identify preeclampsia and thus give close monitoring and appropriate treatment to those at high risk of SLE and APS is of critical importance to improving maternal and fetal outcomes.The use of low dose aspirin as preeclampsia prevention in SLE and APS pregnancy may be the best choice by now.

关 键 词：子痫前期 系统性红斑狼疮 抗磷脂综合征 

分 类 号：R714.244[医药卫生—妇产科学]