相溶解度法研究环糊精对奥美沙坦酯的增溶作用  

Study on the solubilization effect of β-cyclodextrins on olmesartan medoxomil by phase solubility method

作　　者：王云龙[1] 任强[1] 全先高[1] 李伟[1] 王慧云[1] 盛筱[1] WANG Yun-long;REN Qiang;QUAN Xian-gao;LI Wei;WANG Hui-yun;SHENG Xiao(School of Pharmy, Jining Medical University, Rizhao 27682)

机构地区：[1]济宁医学院药学院,日照276826

出　　处：《分析试验室》2018年第5期564-567,共4页Chinese Journal of Analysis Laboratory

基　　金：济宁医学院青年基金项目(JYQ2011KM025);济宁医学院大学生创新训练计划立项项目(cx2016005)资助;山东省医药卫生科技发展计划项目(2014WS0508)

摘　　要：研究了3种环糊精对奥美沙坦酯药物的增溶效果。建立了高效液相色谱法测定环糊精溶液中奥美沙坦酯药物含量的方法,利用相溶解度法测定了奥美沙坦酯在不同浓度的β-环糊精(β-CD)、甲基-β-环糊精(M-β-CD)、羟丙基-β-环糊精(HP-β-CD)溶液中的溶解度,并绘制了相溶解度曲线。在0~15 mmol/L环糊精浓度范围内,奥美沙坦酯的溶解度随3种环糊精浓度的增加而线性增加,相溶解度曲线呈AL型,奥美沙坦酯与3种环糊精均是1:1的比例包合;3种环糊精对奥美沙坦酯均有显著的增溶作用且羟丙基-β-环糊精的增溶效果最佳,其次为甲基-β-环糊精和β-环糊精。The solubilization effects of β-cyclodextrins on olmesartan medoxomil（ OM） was investigated in aqueous solution. A method based on high performance liquid chromatography（ HPLC） to determine OM was established in β-cyclodextrins solutions. The solubilization effect of β-cyclodextrins including β-cyclodextrin（ β-CD）,Methyl-β-cyclodextrin（ M-β-CD） and Hydroxyl-β-cyclodextrin（ HP-β-CD） on olmesartan medoxomil was assessed by phase solubility method and the phase-solubility diagrams were obtained. The solubility of OM increased linearly as a function of β-CD,M-β-CD and HP-β-CD concentrations,in the range of 0 ～ 15 mmol/L. Phase-solubility diagrams were classified as typical ALtype,indicating a 1： 1 molecular complex formation for the system of β-CDs and OM. And HP-β-CD provided the best solubility enhancement,followed by DM-β-CD and β-CD.

关 键 词：奥美沙坦酯 环糊精 相溶解度法 高效液相 

分 类 号：O657[理学—分析化学]