液相色谱-串联质谱在农药残留测定中的应用  

Application of liquid chromatography-tandem mass spectrometry in the determination of pesticide residues

作　　者：王晨晨 李慧冬[1,2] 方丽萍 丁蕊艳[1,2] 张文君 毛江胜[1,2] 郭长英 陈子雷[1,2] 杨国生 WANG Chen-chen;LI Hui-dong;FANG Li-ping;DING Rui-yan;ZHANG Wen -jun;MAO Jiang - sheng;GUO Chang - ying;CHEN Zi-lei;YANG Guo-sheng(Institution of Quality Standard and Testing Technology for Agro-product, Shandong Academy of Agricultural Science, Jinan 250100;Shandong Provincial Key Laboratory of Testing Technology for Food Quality and Security, Jinan 250100;School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100)

机构地区：[1]山东省农业科学院农业质量标准与检测技术研究所,济南250100 [2]山东省食品质量与安全检测技术重点实验室,济南250100 [3]山东大学化学与化工学院,济南250100

出　　处：《分析试验室》2018年第5期614-620,共7页Chinese Journal of Analysis Laboratory

基　　金：现代农业产业技术体系建设专项资金(CARS-28);山东省自主创新项目(2014ZZCX02703)资助

摘　　要：农药残留检测已经成为全球食品安全的重要组成部分。许多国家和国际组织都制定了严格的限量标准,规定了农产品中农药最大残留限量(MRLs),保证食品安全及进出口贸易。随着农药残留被广泛重视,分析方法不断发展,液相色谱-串联质谱因其高选择性、高灵敏度成为农药残留分析中最常用的检测技术之一。本文简述了最近两年液相色谱-串联质谱在农药残留分析中的应用,介绍了固相萃取及Qu ECh ERS净化方法、液相色谱分离以及串联质谱检测技术,包括低分辨串联质谱和高分辨串联质谱。Pesticides residue analysis has become an important component of global food safety. Many countries and international organizations have established strict standards and set the maximum residue limits（ MRLs） for pesticides in agricultural products,guaranteeing food safety and ensuring import and export trade. Liquid chromatography-tandem mass spectrometry（ LC-MS/MS） has become a powerful technique for pesticide residue analysis due to its high specificity and sensitivity. This paper is to review the sample preparation and detection technologies of pesticide residues. The solid phase extraction（ SPE） and Qu ECh ERS are introduced as well as liquid chromatography-tandem mass spectrometry（ LC-MS/MS）,including the liquid chromatography separation and the application of low resolution tandem mass spectrometry and the high resolution tandem mass spectrometry.

关 键 词：农药残留 液相色谱-串联质谱 固相萃取 QUECHERS 基质效应 

分 类 号：O65[理学—分析化学]