NT-proBNP评估无心衰症状尿毒症患者容量负荷的临床研究  

A clinical study of NT-proBNP assessment of capacity load in patients with no heart failure in uremia

作　　者：徐敏[1] 李中[1] 杨中香[1] 刘国梅[1] Xu Min;Li Zhong;Yang Zhongxiang;Liu Guomei(Depaztment of Nephrology, the Second People＇s Hospital of Jingzhou City（Hubei Province）43400)

机构地区：[1]荆州市第二人民医院肾内科,湖北434000

出　　处：《中国社区医师》2018年第15期126-127,共2页Chinese Community Doctors

摘　　要：目的:观察无心衰症状尿毒症患者透析前血浆N末端B型脑钠肽前体(NT-proBNP)水平在容量负荷评估中的临床价值。方法:回顾性分析无心衰症状尿毒症患者62例透析前收缩压、血肌酐、全身水肿程度及脱水量,并进行血浆NT-proBNP水平与上述各项指标的相关性研究。结果:透析前血浆NT-proBNP水平(5 111.9±2 783.6)pg/m L,与收缩压、血肌酐水平、脱水量及全身水肿程度呈明显正相关(P<0.05)。结论:血NT-proBNP水平可能是判断早期容量负荷过高的一个敏感指标,对临床容量负荷评估有重要的意义。Objective：To observe the clinical value of the level of N terminal B type natriuretic peptide（NT-pro BNP）in the volume load assessment of patients with uremia without heart failure before dialysis.Methods：We made a retrospective analysis of 62 cases of uremic patients with non heart failure symptoms,including pre dialysis systolic blood pressure,serum creatinine, systemic edema and dehydration,and the correlation between plasma NT-pro BNP level and the above indicators were performed. Results：The level of plasma NT-pro BNP was（5 111.9 ± 2 783.6）pg/mL before dialysis was positively correlated with the systolic pressure,serum creatinine level,dewater and the degree of systemic edema（P 〈 0.05）.Conclusion：The level of serum NT-pro BNP mW be a sensitive index to judge the early volume overload,which is of great significance for the assessment of clinical volume load.

关 键 词：NT—proBNP 尿毒症 透析 容量负荷心衰 

分 类 号：R541.6[医药卫生—心血管疾病] R692.5[医药卫生—内科学]