随机尿微量白蛋白与肌酐比值对2型糖尿病肾病的早期诊断价值  

Value of random urinary albumin to creatinine ratio for early diagnosis of type 2 diabetic nephropathy

作　　者：刘建广[1] 王新[2] LIU Jian-guang;WANG Xin(Department of Clinical Laboratory, Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China;Department of Anesthesiology, General Hospital, Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, China)

机构地区：[1]天津医科大学代谢病医院检验科,天津300070 [2]天津医科大学总医院麻醉科,天津市麻醉学研究所,天津300052

出　　处：《天津医科大学学报》2018年第3期224-225,228,共3页Journal of Tianjin Medical University

基　　金：天津医科大学代谢病医院内分泌研究所科学基金(2012DX07)

摘　　要：目的:探讨随机尿微量白蛋白与肌酐比值在2型糖尿病早期肾损伤诊断中的临床应用价值。方法:以459例2型糖尿病患者及97例健康体检者为研究对象,采用速率散射比浊法测定随机尿中微量白蛋白(m ALB)和肌酐(Cr)含量,并计算m ALB与Cr的比值(ACR)。与24 h微量尿白蛋白定量结果进行线性回归分析,确定其相关性。以尿白蛋白排泄率>20 mg/24 h为诊断标准,计算ACR诊断糖尿病肾病的特异性和灵敏度,并初步确定其医学决定水平。结果:随机尿ACR与24 h尿微量白蛋白定量值相关性分析r=0.738(P<0.01)呈正相关,具有统计学意义,ACR的医学决定水平为2.285 mg/mmol。结论:ACR高于2.285 mg/mmol时,提示医生进行早期干预治疗。Objective： To investigate the value of urinary albumin to ereatinine ratio （ACR） for early diagnosis of Upe 2 diabetic nephropathy. Methods： The mieroalbumin （mALB） and ereatinine （Cr） content in random urine of 459 type 2 diabetic patients nephropathy and 97 heahhy people was detected through immunoturbidimetrie assay, and the ratio of mALB to Cr （ACR） was determined. Linear regression analysis was used to determine the correlation between the resuhs of ACR and urine persistant mALB. Urinary protein excretion rate 〉20 mg/min was set as the diagnostic criteria to calculate the specificity and sensitivity of ACR in the diagnosis of diabetic nephropathy, and the medical decision level was preliminarily determined. Results： The correlation analysis between random urine ACR and 24 h urine albumin showed a positive correlation between them, with statistical significance [r =0.738 （P 〈0.01）], and the medical decision level of ACR was 2.285 （mg/mmool）. Conclusion： When ACR is higher than 2.285 （mg/mmol）, doctors should perform early intervention.

关 键 词：尿微量白蛋白与肌酐比值 糖尿病肾病 医学决定水平 

分 类 号：R587.1[医药卫生—内分泌]